The Effects of Corticosteroid Administration and Treadmill Exercise on Marrow Adipose Tissue and Trabecular Bone after Anterior Cruciate Ligament Reconstruction in Rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-23 DOI:10.1267/ahc.23-00068

Akinori Kaneguchi, Kaoru Yamaoka, Junya Ozawa

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Abstract

We aimed to investigate the effects of short-term corticosteroid administration after anterior cruciate ligament (ACL) reconstruction on marrow adipose tissue (MAT) and trabecular bone mass, as well as to examine whether treadmill exercise can mitigate MAT increase and trabecular bone deterioration caused by corticosteroid. ACL-reconstructed rats were divided into groups: no intervention, daily treadmill exercise (60 min/day), administration of the steroidal drug dexamethasone (250 μg/kg on days 0–5, 7, and 9 post-operatively), or dexamethasone administration combined with treadmill exercise. Untreated rats were served as controls. At day 10 or 30 post-operatively, histological assessments were performed in the proximal tibial epiphysis. MAT accumulation and trabecular bone loss were observed after ACL reconstruction. Dexamethasone promoted MAT accumulation at day 10 post-operatively but did not affect the trabecular bone loss. The MAT accumulation caused by dexamethasone reversed within 21 days after discontinuation. Treadmill exercise did not influence the changes in the MAT and trabecular bone areas. Short-term corticosteroid administration after ACL reconstruction promoted MAT accumulation while not affecting trabecular bone area. The MAT accumulation resulting from corticosteroid administration was reversible after discontinuation. Treadmill exercise could not mitigate the accumulation of MAT caused by corticosteroid administration and did not affect trabecular bone area.

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皮质类固醇给药和跑步机运动对大鼠前十字韧带重建后骨髓脂肪组织和骨小梁的影响

我们的目的是研究前交叉韧带（ACL）重建后短期皮质类固醇用药对骨髓脂肪组织（MAT）和骨小梁质量的影响，以及研究跑步机运动是否能缓解皮质类固醇引起的骨髓脂肪组织（MAT）增加和骨小梁恶化。将前交叉韧带重建大鼠分为以下几组：不进行干预、每天进行跑步机运动（60 分钟/天）、服用类固醇药物地塞米松（250 μg/kg，分别在术后第 0-5、7 和 9 天服用）或服用地塞米松的同时进行跑步机运动。未经处理的大鼠作为对照组。术后第 10 天或第 30 天，对胫骨近端骨骺进行组织学评估。在前交叉韧带重建术后，观察到MAT积聚和骨小梁丢失。地塞米松促进了术后第10天的MAT积聚，但并不影响骨小梁的丢失。地塞米松导致的 MAT 积聚在停药后 21 天内逆转。跑步机运动对 MAT 和骨小梁面积的变化没有影响。前交叉韧带重建后短期使用皮质类固醇会促进 MAT 的积累，但不会影响骨小梁面积。停用皮质类固醇后，MAT积聚可逆。跑步机运动无法缓解皮质类固醇用药导致的 MAT 积聚，也不会影响骨小梁面积。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.