Higher cortical excitability to negative emotions involved in musculoskeletal pain in Parkinson's disease

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2024-02-01 DOI:10.1016/j.neucli.2023.102936

Ming Liu , Hanying Gu , Jingzhe Hu , Manhua Liu , Yajun Luo , Yuan Yuan , Jiayu Wu , Yan Zhou , Ru Juan , Xiaoyu Cheng , Sheng Zhuang , Yun Shen , Hong Jin , Jing Chen , Kai Li , Fen Wang , Chunfeng Liu , Chengjie Mao

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引用次数: 0

Abstract

Objective

Changes in brain structure and neurotransmitter systems are involved in pain in Parkinson's disease (PD), and emotional factors are closely related to pain. Our study applied electroencephalography (EEG) to investigate the role of emotion in PD patients with chronic musculoskeletal pain.

Methods

Forty-two PD patients with chronic musculoskeletal pain and 38 without were enrolled. EEG data were recorded under resting conditions, and while viewing pictures with neutral, positive, and negative content. We compared spectrum power, functional connectivity, and late positive potential (LPP), an event-related potential (ERP), between the groups.

Results

PD patients with pain tended to have higher scores for the Hamilton Rating Scale for Depression (HRSD). In the resting EEG, mean β-band amplitude was significantly higher in patients with pain than in those without. Logistic regression analysis showed that higher HRSD scores and higher mean β-band amplitude were associated with pain. ERP analysis revealed that the amplitudes of LPP difference waves (the absolute difference between positive and negative condition LPP and neutral condition LPP) at the central–parietal region were significantly reduced in patients with pain (P = 0.029). Spearman correlation analysis showed that the amplitudes of late (700–1000 ms) negative versus neutral condition LPP difference waves were negatively correlated with pain intensity, assessed by visual analogue scale, (r = −0.393, P = 0.010) and HRSD scores (r = −0.366, P = 0.017).

Conclusion

Dopaminergic and non-dopaminergic systems may be involved in musculoskeletal pain in PD by increasing β-band activity and weakening the connection of the θ-band at the central–parietal region. PD patients with musculoskeletal pain have higher cortical excitability to negative emotions. The changes in pain-related EEG may be used as electrophysiological markers and therapeutic targets in PD patients with chronic pain.

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帕金森病患者大脑皮层对涉及肌肉骨骼疼痛的负面情绪的兴奋性更高

目的帕金森病（PD）患者的疼痛与大脑结构和神经递质系统的变化有关，而情绪因素与疼痛密切相关。我们的研究采用脑电图（EEG）来研究情绪在帕金森病慢性肌肉骨骼疼痛患者中的作用。我们记录了静息状态下以及观看中性、积极和消极内容图片时的脑电图数据。我们比较了两组患者的频谱功率、功能连通性和晚期正电位（LPP）（一种事件相关电位（ERP））。在静息脑电图中，疼痛患者的平均β波段振幅明显高于非疼痛患者。逻辑回归分析表明，HRSD评分越高，平均β波段振幅越大，则疼痛越严重。ERP分析显示，疼痛患者中央顶叶区的LPP差异波（正负状态LPP与中性状态LPP的绝对差值）振幅明显降低（P = 0.029）。斯皮尔曼相关分析表明，晚期（700-1000 毫秒）阴性与中性状态 LPP 差异波的振幅与视觉模拟量表评估的疼痛强度呈负相关（r = -0.393，P = 0.结论多巴胺能系统和非多巴胺能系统可能通过增加 β 波段活动和减弱中央顶叶区 θ 波段的连接参与了帕金森病肌肉骨骼疼痛。患有肌肉骨骼疼痛的帕金森病患者大脑皮层对负面情绪的兴奋性更高。疼痛相关脑电图的变化可作为慢性疼痛的帕金森病患者的电生理标记和治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.