Regulation of Intestinal Flora and Immune Response by Cyanidin Exhibits Protective Effect against Type-2 Diabetes in Rat Model

IF 0.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qingyan Lu, Qiannan Yan, Xiaojie Li
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Abstract

In the current study the effects of metformin and cyanidin on the immune system and intestinal flora in rats with type-2 diabetes was investigated. The findings showed that metformin or cyanidin treatment considerably reduced the rise in body weight and glucose levels induced by type-2 diabetes. The type-2 diabetic rats’ glucose tolerance was significantly increased by cyanidin administration comparable to that of metformin. Cyanidin administration resulted in a significant reduction in serum cholesterol and low-density lipoprotein (LDL) levels in rats with type-2 diabetes. Treatment with cyanidin significantly increased the ratio of high-density lipoprotein to low-density lipoprotein in type-2 diabetes rats. Cyanidin administration significantly raised the ratio of Firmicutes to Bacteroidetes in the fecal samples of type-2 diabetic rats compared to the model group. In comparison to the model group, it also significantly raised the levels of Lactobacillus intestinalis, Lactobacillus gasseri, and Lactobacillus reuteri in the type-2 diabetes rats. In type-2 diabetes rat fecal samples, the abundance of Christensenellaceae significantly increased while Enterobacteriaceae and Proteobacteria were found to decrease upon cyanidin administration. Furthermore, cyanidin administration to the rats with type-2 diabetes significantly improved the glucose homeostasis. In conclusion, the study demonstrates that cyanidin enhances glucose homeostasis in rats with type-2 diabetes, potentially through controlling intestinal flora. Thus, cyanidin may be looked into more as a possible therapeutic agent for type 2 diabetes.

Abstract Image

Abstract Image

矢车菊素调节肠道菌群和免疫反应对大鼠模型中的 2 型糖尿病有保护作用
本研究调查了二甲双胍和青花素对 2 型糖尿病大鼠免疫系统和肠道菌群的影响。研究结果表明,二甲双胍或青花素能显著降低 2 型糖尿病大鼠体重和血糖水平的升高。与二甲双胍相比,服用青花素能显著提高 2 型糖尿病大鼠的葡萄糖耐量。服用青花素可显著降低 2 型糖尿病大鼠的血清胆固醇和低密度脂蛋白(LDL)水平。青花素能显著提高 2 型糖尿病大鼠体内高密度脂蛋白与低密度脂蛋白的比率。与模型组相比,青花素能明显提高2型糖尿病大鼠粪便样本中的固缩菌与类杆菌的比例。与模型组相比,青花素还能显著提高 2 型糖尿病大鼠肠道乳杆菌、加塞利乳杆菌和吕特氏乳杆菌的含量。在 2 型糖尿病大鼠的粪便样本中,发现在施用青花素后,Christensenellaceae 的丰度显著增加,而 Enterobacteriaceae 和 Proteobacteria 则减少。此外,给 2 型糖尿病大鼠服用青花素还能明显改善其血糖稳态。总之,该研究表明,青花素可通过控制肠道菌群改善 2 型糖尿病大鼠的葡萄糖稳态。因此,可将青花素作为一种治疗 2 型糖尿病的药物进行更多研究。
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来源期刊
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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