Association between blood lipid levels and the risk of liver cancer: a systematic review and meta-analysis.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Causes & Control Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI:10.1007/s10552-024-01853-9

Zhihui Zhang, Shicong Xu, Meixuan Song, Weirong Huang, Manlin Yan, Xianrong Li

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引用次数: 0

Abstract

Purpose: The association between blood lipid levels and the risk of developing liver cancer remains a subject of ongoing debate. To elucidate this association, we conducted a meta-analysis by systematically incorporating data from all relevant prospective cohort studies.

Methods: We conducted a systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases covering studies published from database inception through July 2023. This study included prospective cohort studies related to lipid profiles (e.g., total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels) that reported hazard ratios (HRs) or relative risks (RRs) with corresponding 95% confidence intervals (95% CIs) to investigate their association with the risk of liver cancer. During the analysis process, we used fixed-effects or random-effects models based on the level of heterogeneity among the studies and obtained pooled risk ratios using these models. To ensure the robustness and reliability of the study findings, we also conducted sensitivity analyses and publication bias analyses.

Results: After conducting a systematic search, 12 studies were identified from a total of 11,904 articles and were included in the meta-analysis. These studies included a combined population of 10,765,221 participants, among whom 31,055 cases of liver cancer were reported. The analysis revealed that the pooled HR for the serum TC concentration (highest versus lowest) was 0.45 (95% CI = 0.35-0.58, I² = 78%). For TGs, the HR was 0.67 (95% CI = 0.46-0.96, I² = 86%), while for HDL-C, the HR was 0.72 (95% CI = 0.58-0.90, I² = 65%). The HR for LDL-C was 0.51 (95% CI = 0.23-1.13, I² = 93%).

Conclusion: The findings of this study indicate that serum TC, TG, and HDL-C levels are negatively associated with liver cancer risk, suggesting that higher concentrations of these lipids are associated with a reduced risk of liver cancer. However, no significant association has been found between LDL-C levels and liver cancer risk.

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查看原文本刊更多论文

血脂水平与肝癌风险之间的关系：系统回顾和荟萃分析。

目的：血脂水平与肝癌发病风险之间的关系仍是一个争论不休的话题。为了阐明这种关联，我们系统地纳入了所有相关前瞻性队列研究的数据，进行了一项荟萃分析：我们对 PubMed、Embase、Web of Science 和 Cochrane Library 数据库进行了系统检索，涵盖了从数据库建立到 2023 年 7 月期间发表的研究。本研究纳入了与血脂概况（如总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平）相关的前瞻性队列研究，这些研究报告了危险比（HRs）或相对危险度（RRs）及相应的 95% 置信区间（95% CIs），以调查它们与肝癌风险的关系。在分析过程中，我们根据研究之间的异质性程度使用固定效应或随机效应模型，并通过这些模型获得汇总风险比。为确保研究结果的稳健性和可靠性，我们还进行了敏感性分析和发表偏倚分析：经过系统检索，我们从 11904 篇文章中筛选出 12 项研究，并将其纳入荟萃分析。这些研究共纳入了10,765,221名参与者，其中有31,055例肝癌病例。分析结果显示，血清 TC 浓度（最高与最低）的汇总 HR 为 0.45（95% CI = 0.35-0.58，I2 = 78%）。TGs的HR为0.67（95% CI = 0.46-0.96，I2 = 86%），而HDL-C的HR为0.72（95% CI = 0.58-0.90，I2 = 65%）。低密度脂蛋白胆固醇的 HR 为 0.51（95% CI = 0.23-1.13，I2 = 93%）：本研究结果表明，血清总胆固醇、总胆固醇和高密度脂蛋白胆固醇水平与肝癌风险呈负相关，表明这些血脂浓度越高，肝癌风险越低。然而，低密度脂蛋白胆固醇（LDL-C）水平与肝癌风险之间并无明显关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.