Retrospective analysis of cytology and high-risk HPV testing in 1067 endocervical adenocarcinomas and precursor lesions

IF 2.6 3区 医学 Q3 ONCOLOGY
Lei Ye, Meifu Gan, Yeli Yao, Bingjian Lu
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引用次数: 0

Abstract

The detection efficacy of cytology and high-risk human papillomavirus (hrHPV) cotesting has been analyzed in a large cohort of patients with cervical glandular lesions. Cotesting can maximize the detection effect for adenocarcinoma in situ and HPV-associated adenocarcinoma; however, cytology and hrHPV cotesting is not optimal for HPV-independent adenocarcinoma.

对 1067 例宫颈内膜腺癌和前驱病变进行细胞学和高危 HPV 检测的回顾性分析。
背景:细胞学和高危人乳头瘤病毒(hrHPV)联合检测是检测宫颈癌的主要方法:方法:根据世界卫生组织的分类(2020 年),宫颈内膜腺癌(EAC)分为 HPV 相关性腺癌(HPVA)和 HPV 非相关性腺癌(HPVI)。有观点认为,EAC亚型和前体之间的联检检测效果不同,但尚未得到充分证实。在这项研究中,作者回顾性分析了原位腺癌(AIS)、HPVA和HPVI之间的联检。队列包括 569 例 AIS 和 498 例 EAC,其中 371 例(74.5%)为 HPVA,111 例(22.3%)为 HPVI,16 例(3.2%)为腺癌,未作其他说明:作者发现,AIS 患者明显比 HPVA 和 HPVI 患者年轻(平均年龄为 40.7±8.6 岁;平均年龄为 40.7±8.6 岁;平均年龄为 40.7±8.6 岁):40.7±8.6;HPVA,44.8±9.3;HPVI,50.0±11.3;P 结论:作者得出结论:细胞学和 hrHPV 联合检测可最大限度地提高 HPVA 和 AIS 的检测效果,但对 HPVI 而言并非最佳选择。
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来源期刊
Cancer Cytopathology
Cancer Cytopathology 医学-病理学
CiteScore
7.00
自引率
17.60%
发文量
130
审稿时长
1 months
期刊介绍: Cancer Cytopathology provides a unique forum for interaction and dissemination of original research and educational information relevant to the practice of cytopathology and its related oncologic disciplines. The journal strives to have a positive effect on cancer prevention, early detection, diagnosis, and cure by the publication of high-quality content. The mission of Cancer Cytopathology is to present and inform readers of new applications, technological advances, cutting-edge research, novel applications of molecular techniques, and relevant review articles related to cytopathology.
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