Protective Effect of Protocatechuic Acid on Oxidative Damage and Cognitive Impairment in Pb-Induced Rats.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-19 DOI:10.1007/s12011-024-04095-7
Yao Chen, Lu Sun, Hengyu Shi, Guanghua Mao, Ting Zhao, Weiwei Feng, Liuqing Yang, Xiangyang Wu
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Abstract

Protocatechuic acid (PCA), a class of water-soluble phenolic acid abundant in the human diet, has been shown to be of great nutritional interest and to have medicinal value. However, the protective effects against lead (Pb)-induced body injury have not been elucidated. In this study, we explored the protective effect of PCA on Pb-induced oxidative damage and cognitive impairment in rats. The results showed that PCA could reduce the Pb content in rat bodies (blood, bone, brain, liver, and kidney) after Pb exposure. Moreover, PCA may inhibit Pb-induced oxidative damage by increasing the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreasing the level of malondialdehyde (MDA) in the brain, liver, and kidney. In addition, PCA may alleviate Pb-induced learning and memory impairment by upregulating neurotransmitter levels; maintaining the normal function of N-methyl-D-aspartate receptors (NMDARs); and promoting Ca2+ influx, thus activating signaling molecules, related protein kinases, and transcription factors in the cAMP-PKA-CREB pathway. In general, PCA could reduce oxidative stress and ameliorate the learning and memory deficits in Pb-treated rats, indicating that PCA may be an effective preventive agent and treatment or plumbism.

原儿茶酸对铅诱导大鼠氧化损伤和认知障碍的保护作用
原儿茶酸(PCA)是一类水溶性酚酸,在人类饮食中含量丰富,已被证明具有重要的营养价值和药用价值。然而,其对铅(Pb)引起的身体损伤的保护作用尚未得到阐明。在本研究中,我们探讨了五氯苯甲醚对铅诱导的大鼠氧化损伤和认知障碍的保护作用。结果表明,PCA 可降低大鼠体内(血液、骨骼、大脑、肝脏和肾脏)暴露于铅后的铅含量。此外,五氯苯甲醚还能提高超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)等抗氧化酶的活性,降低脑、肝和肾中丙二醛(MDA)的含量,从而抑制铅引起的氧化损伤。此外,五氯苯甲醚还可通过上调神经递质水平、维持 N-甲基-D-天冬氨酸受体(NMDARs)的正常功能、促进 Ca2+ 流入从而激活 cAMP-PKA-CREB 通路中的信号分子、相关蛋白激酶和转录因子,减轻铅诱导的学习和记忆损伤。总的来说,五氯苯甲醚能降低氧化应激,改善铅处理大鼠的学习和记忆缺陷,表明五氯苯甲醚可能是一种有效的预防和治疗铅中毒的药物。
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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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