Molecularly imprinted polymers based on attapulgite and sustained-release properties for 5-FU

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-02-17 DOI:10.1007/s00396-024-05237-y

Xinyuan Ji, Zhe Yang, Jiahui Fang, Sheng Hu

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Abstract

In this study, a novel molecularly imprinted polymer (MIP) was synthesized with attapulgite (ATP) and acrylamide (AM) and ethyl methacrylate (MMA) for controlled release carrier of 5-fluorouracil (5-FU). The MIPs (PAM-PMMA) were characterized by XRD, FESEM, HRTEM, and FTIR. The drug loading and in vitro controlled release ability of MIP on 5-FU was investigated by adsorption property analysis and in vitro release analysis. MIPs (PAM-PMMA) reached a maximum drug loading of 12 mg/g and a maximum release of 80% at an ATP dosage of 0.2 g (0.4%), an initial concentration of 5-FU of 100 mg/L, and an adsorption time of 240 min. Cytotoxicity analysis showed that the maximum inhibition of cells could reach 25% at 72 h of cell culture time under the above conditions. The results showed that MIPs synthesized with ATP as the substrate and AM and MMA as the functional monomers were successfully synthesized and could be used as a drug delivery system for 5-FU.

Graphical Abstract

Abstract Image

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基于阿塔蓬石的分子印迹聚合物和 5-FU 的缓释特性

本研究用阿塔蓬石（ATP）、丙烯酰胺（AM）和甲基丙烯酸乙酯（MMA）合成了一种新型分子印迹聚合物（MIP），用于 5-氟尿嘧啶（5-FU）的控释载体。通过 XRD、FESEM、HRTEM 和 FTIR 对 MIPs（PAM-PMMA）进行了表征。通过吸附性能分析和体外释放分析，研究了 MIP 对 5-FU 的药物负载和体外控释能力。在ATP用量为0.2克（0.4%）、5-FU初始浓度为100毫克/升、吸附时间为240分钟时，MIP（PAM-PMMA）的最大药物负载量为12毫克/克，最大释放量为80%。细胞毒性分析表明，在上述条件下，细胞培养 72 小时后，对细胞的最大抑制率可达 25%。结果表明，以ATP为底物，AM和MMA为功能单体的MIPs合成成功，可用作5-FU的给药系统。

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.