Bilateral tonic pupils secondary to anti-GD2 antibody therapy for neuroblastoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-01 DOI:10.1016/j.jaapos.2024.103852

Christopher M. Edwards BS , Daniel Elefant MD , Michael S. Isakoff MD , Majida A. Gaffar MD

引用次数: 0

Abstract

We report the case of a 12-year-old girl with stage 4 neuroblastoma who developed tonic pupils secondary to immunotherapy with dinutuximab, an anti-GD2 antibody, based on the timeline provided by her mother with regard to onset of symptoms. The patient presented with difficulty reading and chronic dilated pupils bilaterally, according to her mother’s observations over 6 months prior to presentation. Testing with dilute pilocarpine supported our presumption of tonic pupils.

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继发于神经母细胞瘤抗GD2抗体治疗的双侧强直性瞳孔。

我们报告了一例患有神经母细胞瘤 4 期的 12 岁女孩的病例，根据其母亲提供的发病时间表，该女孩在使用抗 GD2 抗体地纽昔单抗（dinutuximab）进行免疫治疗后出现了强直性瞳孔。根据其母亲在发病前 6 个月的观察，患者出现阅读困难和双侧瞳孔长期散大。使用稀释的皮洛卡品进行的测试证实了我们的推测，即瞳孔强直。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.