Concurrent use of two dual-combination drenches containing monepantel/abamectin and oxfendazole/levamisole in sheep: effect on marker residues 21 and 28 days after administration.

IF 1.1 4区 农林科学 Q3 VETERINARY SCIENCES
New Zealand veterinary journal Pub Date : 2024-05-01 Epub Date: 2024-02-18 DOI:10.1080/00480169.2024.2314494
C H McKay, K E Baker, K J VanHoff, C Smith, S D George
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引用次数: 0

Abstract

Aims: To determine the concentration, in comparison with the maximum residue limit (MRL), of anthelmintic marker residues in the target tissues (liver and fat) of sheep treated concurrently with two oral drenches, one containing monepantel and abamectin and the other oxfendazole and levamisole.

Methods: On day 0 of the study, 12 sheep (six male and six female; 8-9-months old) were dosed according to individual body weight determined the day prior. Zolvix Plus (dual-active oral drench containing 25 g/L monepantel and 2 g/L abamectin) was administered to all animals prior to administration of Scanda (dual-active oral drench containing 80 g/L levamisole hydrochloride and 45.3 g/L oxfendazole). Six sheep (three male and three female) were slaughtered 21 and 28 days after treatment and renal fat and liver samples were collected.Using validated methods, analyses for monepantel sulfone, abamectin, levamisole and oxfendazole (expressed as total fenbendazole sulfone following conversion of the combined concentrations of oxfendazole, fenbendazole and fenbendazole sulfone) were performed on liver samples while renal fat specimens were analysed for monepantel sulfone and abamectin residues only. Detected concentrations were compared to the established MRL in sheep for each analyte determined by the Ministry for Primary Industries.

Results: All residues detected in samples of liver and fat collected 21 and 28 days after treatment were below the MRL for each analyte. All liver samples collected on day 21 had detectable monepantel sulfone (mean 232 (min 110, max 388) μg/kg) and oxfendazole (mean 98.7 (min 51.3, max 165) μg/kg) residues below the MRL (5,000 and 500 μg/kg, respectively). Monepantel sulfone (mean 644 (min 242, max 1,119) μg/kg; MRL 7,000 μg/kg) residues were detected in 6/6 renal fat samples. Levamisole residues were detected in 3/6 livers (mean 40.0 (min 14.3, max 78.3) μg/kg; MRL 100 μg/kg), and abamectin residues in 1/6 livers (0.795 μg/kg; MRL 25 μg/kg) and 2/6 fat samples, (mean 0.987 (min 0.514, max 1.46) μg/kg; MRL 50 μg/kg) 21 days after treatment.

Conclusion and clinical relevance: These results suggest that concurrent administration of Zolvix Plus and Scanda to sheep is unlikely to result in an extended residue profile for any of the active ingredients, with all analytes measured being under the approved New Zealand MRL 21 days after treatment. This work was not completed in line with guidance for establishing official residue profiles, nor is it sufficient to propose a new withholding period.

在绵羊中同时使用含有莫尼菌素/阿维菌素和奥芬多唑/左旋咪唑的两种双效复合浸液:用药 21 天和 28 天后对标记物残留的影响。
目的:测定同时使用两种口服浸液(一种含有莫尼潘特尔和阿维菌素,另一种含有奥克芬达唑和左旋咪唑)的绵羊目标组织(肝脏和脂肪)中抗蠕虫药物标记物的残留浓度,并与最大残留限量(MRL)进行比较:在研究的第 0 天,12 只绵羊(6 公 6 母,8-9 个月大)根据前一天确定的个体体重进行配药。在使用 Scanda(含 80 克/升盐酸左旋咪唑和 45.3 克/升奥克斯芬达唑的双效口服淋洗剂)之前,给所有动物使用 Zolvix Plus(含 25 克/升莫奈潘特尔和 2 克/升阿维菌素的双效口服淋洗剂)。六只绵羊(三雄三雌)在治疗后 21 天和 28 天被宰杀,并采集了肾脏脂肪和肝脏样本。采用经过验证的方法,对肝脏样本进行了莫尼苯砜、阿维菌素、左旋咪唑和奥芬达唑(将奥芬达唑、芬苯达唑和芬苯达唑砜的总浓度换算后表示为芬苯达唑砜总量)分析,而对肾脏脂肪样本仅进行了莫尼苯砜和阿维菌素残留分析。将检测到的浓度与初级产业部确定的每种分析物在绵羊中的最大残留限量进行比较:处理后 21 天和 28 天采集的肝脏和脂肪样本中检测到的所有残留物均低于每种分析物的最高残留限量。在第 21 天采集的所有肝脏样本中检测到的莫尼潘特砜(平均 232(最低 110,最高 388)微克/千克)和奥芬他唑(平均 98.7(最低 51.3,最高 165)微克/千克)残留量均低于最高残留限量(分别为 5,000 和 500 微克/千克)。在 6/6 份肾脏脂肪样本中检测到 Monepantel 磺酮残留(平均值为 644(最低 242,最高 1 119)微克/千克;最高残留限量为 7,000 微克/千克)。治疗 21 天后,在 3/6 个肝脏样本(平均 40.0(最低 14.3,最高 78.3)微克/千克;最高残留限量 100 微克/千克)中检测到左旋咪唑残留,在 1/6 个肝脏样本(0.795 微克/千克;最高残留限量 25 微克/千克)和 2/6 个脂肪样本(平均 0.987(最低 0.514,最高 1.46)微克/千克;最高残留限量 50 微克/千克)中检测到阿维菌素残留:这些结果表明,同时给绵羊施用 Zolvix Plus 和 Scanda 不可能导致任何活性成分的残留范围扩大,治疗 21 天后测定的所有分析物均低于新西兰批准的最高残留限量。这项工作没有按照建立官方残留概况的指南完成,也不足以提出新的暂停期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
New Zealand veterinary journal
New Zealand veterinary journal 农林科学-兽医学
CiteScore
3.00
自引率
0.00%
发文量
37
审稿时长
12-24 weeks
期刊介绍: The New Zealand Veterinary Journal (NZVJ) is an international journal publishing high quality peer-reviewed articles covering all aspects of veterinary science, including clinical practice, animal welfare and animal health. The NZVJ publishes original research findings, clinical communications (including novel case reports and case series), rapid communications, correspondence and review articles, originating from New Zealand and internationally. Topics should be relevant to, but not limited to, New Zealand veterinary and animal science communities, and include the disciplines of infectious disease, medicine, surgery and the health, management and welfare of production and companion animals, horses and New Zealand wildlife. All submissions are expected to meet the highest ethical and welfare standards, as detailed in the Journal’s instructions for authors.
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