The association of in-utero exposure to air pollution and atherogenic index of plasma in newborns.

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Health Pub Date : 2024-02-19 DOI:10.1186/s12940-024-01059-1

Ali Seidkhani-Nahal, Hafez Heydari, Ayoub Tavakolian, Moslem Lari Najafi, Mohammad Miri

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引用次数: 0

Abstract

Background: Prenatal exposure to particulate matter (PM) and traffic was associated with the programming of cardiovascular diseases (CVDs) in early life. However, the exact underlying mechanisms are not fully understood. Therefore, we aimed to evaluate the association between in-utero exposure to PMs and traffic indicators with the atherogenic index of plasma (AIP) in newborns, which is a precise index reflecting an enhancement of lipid risk factors for CVDs.

Methods: In this cross-sectional study, a total of 300 mother-newborn pairs were enrolled in Sabzevar, Iran. Spatiotemporal land-use regression models were used to estimate the level of PM₁, PM_2.5 and PM₁₀ at the mother's residential address. The total length of streets in different buffers (100,300 and 500m) and proximity to major roads were calculated as indicators of traffic. The AIP of cord blood samples was calculated using an AIP calculator. Multiple linear regression models were used to examine the association of PM concentrations as well as traffic indicators with AIP controlled for relevant covariates.

Results: PM_2.5 exposure was significantly associated with higher levels of AIP in newborns. Each interquartile range (IQR) increment of PM_2.5 concentration at the mothers' residential addresses was associated with a 5.3% (95% confidence interval (CI): 0.0, 10.6%, P = 0.04) increase in the AIP. Associations between PM₁, PM₁₀ and traffic indicators with cord blood level of AIP were positive but not statistically significant.

Conclusion: Our findings showed that in utero exposure to PM_2.5 may be associated with CVDs programming through the increase of atherogenic lipids.

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胎儿期暴露于空气污染与新生儿血浆致动脉粥样硬化指数的关系。

背景：产前接触颗粒物（PM）和交通与早年心血管疾病（CVDs）的发生有关。然而，其确切的内在机制尚未完全明了。因此，我们旨在评估胎儿期暴露于可吸入颗粒物和交通指标与新生儿血浆致动脉粥样硬化指数（AIP）之间的关联：在这项横断面研究中，伊朗 Sabzevar 共登记了 300 对母亲-新生儿。时空土地利用回归模型用于估算母亲居住地的 PM1、PM2.5 和 PM10 水平。计算了不同缓冲区（100 米、300 米和 500 米）内街道的总长度以及与主要道路的距离，作为交通指标。使用 AIP 计算器计算脐带血样本的 AIP。采用多元线性回归模型研究了PM浓度以及交通指标与AIP的关系，并对相关协变量进行了控制：结果：PM2.5暴露与新生儿AIP水平升高有明显关联。母亲居住地的PM2.5浓度每增加一个四分位数间距（IQR），AIP就增加5.3%（95%置信区间（CI）：0.0，10.6%，P = 0.04）。PM1、PM10和交通指标与脐带血中的AIP水平呈正相关，但无统计学意义：我们的研究结果表明，子宫内暴露于PM2.5可能通过增加动脉粥样脂质与心血管疾病的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.