The association between growth differentiation factor 15 and presence and severity of coronary atherosclerosis

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2024-02-17 DOI:10.1016/j.advms.2024.02.003

Emrah Ozdemir , Berna Stavileci , Bahar Ozdemir , Faik Alper Aksoy , Serkan Kahraman , Ceyla Zeynep Colakoglu Gevher , Murat Ziyrek , Ali Dogan

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引用次数: 0

Abstract

Purpose

Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta superfamily and is faintly expressed under healthy conditions. GDF-15 is markedly elevated in a variety of diseases, including coronary artery disease (CAD), atrial fibrillation and heart failure. Here, we aimed to investigate the association of GDF-15 with the extent and severity of CAD in patients with stable CAD.

Methods

We enrolled 129 patients undergoing coronary angiography for the evaluation of stable CAD in the study. SYNTAX and SYNTAX II PCI/CABG scores were calculated. The CAD (+) study group was also stratified into two groups (high and low GDF-15) with respect to the mean GDF-15 value. Correlation and regression analyses were performed for further evaluation.

Results

Of the 129 patients, 75 had CAD. GDF-15 values were higher in the CAD (+) group (p < 0.001). The two groups were compared according to a cut-off value of 2451.77. SYNTAX and SYNTAX II PCI/CABG scores were significantly associated with the high GDF-15 group (p < 0.001). Additionally, correlation analysis showed a strong positive correlation between GDF-15 and SYNTAX (r: 0.859, p < 0.001), SYNTAX II PCI (r: 0.921, p < 0.001) and SYNTAX II CABG (r: 0.874, p < 0.001) scores. Multivariate analysis identified GDF-15 as an independent predictor of CAD.

Conclusion

GDF-15 is an independent predictor of CAD and is associated with CAD severity in terms of SYNTAX, SYNTAX II PCI and SYNTAX II CABG scores.

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生长分化因子 15 与冠状动脉粥样硬化的存在和严重程度之间的关系

目的生长分化因子 15（GDF-15）是转化生长因子 beta 超家族的一员，在健康状态下表达微弱。GDF-15 在多种疾病中明显升高，包括冠状动脉疾病（CAD）、心房颤动和心力衰竭。在此，我们旨在研究 GDF-15 与稳定型 CAD 患者的 CAD 范围和严重程度的关系。计算SYNTAX和SYNTAX II PCI/CABG评分。根据 GDF-15 的平均值，将 CAD（+）研究组分为两组（GDF-15 高和低）。结果在 129 例患者中，75 例患有 CAD。CAD (+) 组的 GDF-15 值较高 (p < 0.001)。根据 2451.77 的临界值对两组进行了比较。SYNTAX和SYNTAX II PCI/CABG评分与高GDF-15组显著相关（p <0.001）。此外，相关性分析表明，GDF-15 与 SYNTAX（r：0.859，p <；0.001）、SYNTAX II PCI（r：0.921，p <；0.001）和 SYNTAX II CABG（r：0.874，p <；0.001）评分之间存在很强的正相关性。结论GDF-15是CAD的独立预测因子，与SYNTAX、SYNTAX II PCI和SYNTAX II CABG评分的CAD严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.