Influence of sleep quality on lapse to alcohol use during a quit attempt.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Wave-Ananda Baskerville, Erica N Grodin, Lara A Ray
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Abstract

Aims: Sleep problems are common among individuals with alcohol use disorder (AUD) and is often associated with a heightened relapse risk. The present study examines the relationship between sleep and alcohol use among individuals with current AUD during a 6-day quit attempt as part of a medication study.

Methods: The current study is a secondary analysis of a medication trial for individuals with AUD. Individuals with AUD (N = 53, 26 females) were randomized to active medication or matched placebo. Randomized participants completed a week-long medication titration (Days 1-7). Following the titration period, participants attended an in-person visit (Day 8) to begin a 6-day quit attempt. During the quit attempt, participants completed daily diary assessments to report on previous day alcohol consumption, sleep quality, and alcohol craving. In the present study, medication condition was controlled for in all models.

Results: Baseline global sleep quality was not a significant predictor of drinks per drinking day (P = 0.72) or percent days abstinent (P = 0.16) during the 6-day practice quit attempt. Daily diary analyses found that greater sleep quality was associated with higher next-day drinks per drinking day (b = 0.198, P = 0.029). In contrast, participants reported worse sleep quality following nights of greater alcohol intake, albeit at a trend-level (b = -0.12, P = 0.053).

Conclusions: These results suggest that better sleep quality was a risk factor for drinking during the 6-day quit period, such that better sleep may be associated with increased craving for alcohol and alcohol use the next day. These findings are limited to the early abstinence period and should be considered in studies exploring longer periods of abstinence.

睡眠质量对戒酒尝试中再次饮酒的影响。
目的:睡眠问题在酒精使用障碍(AUD)患者中很常见,通常与复发风险增加有关。本研究在一项药物治疗研究中,对目前患有酒精使用障碍(AUD)的患者在为期 6 天的戒酒尝试中的睡眠与酒精使用之间的关系进行了研究:本研究是对一项针对 AUD 患者的药物试验进行的二次分析。AUD患者(53人,26名女性)被随机分配到活性药物或匹配的安慰剂中。随机参与者完成为期一周的药物滴定(第 1-7 天)。滴定期结束后,参与者参加一次面访(第 8 天),开始为期 6 天的戒烟尝试。在戒酒尝试期间,参与者每天完成日记评估,报告前一天的酒精消耗量、睡眠质量和对酒精的渴望。在本研究中,所有模型都对用药情况进行了控制:结果:在为期 6 天的戒酒尝试中,基线总体睡眠质量对每饮酒日饮酒量(P = 0.72)或戒酒天数百分比(P = 0.16)没有显著的预测作用。每日日记分析发现,睡眠质量越高,第二天的每日饮酒量越高(b = 0.198,P = 0.029)。与此相反,参与者在酒精摄入量较高的夜晚睡眠质量较差,尽管处于趋势水平(b = -0.12,P = 0.053):这些结果表明,较好的睡眠质量是6天戒酒期间饮酒的一个风险因素,因此较好的睡眠质量可能与第二天对酒精的渴望和饮酒量增加有关。这些发现仅限于早期戒酒期,在探讨更长戒酒期的研究中应加以考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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