Prevalent Oral Drug Delivery System for Dental Care

Abstract

Oral drug delivery systems, including fluoride supplements, constitute one of the most prevalent routes for the administration of medications, playing a crucial role in the treatment and prevention of various diseases, including dental caries. Fluorides, employed as a preventive and control measure against dental caries, are available in two primary forms: systemic fluorides and topical fluorides. Topical fluorides are found in toothpaste, varnish, gels, mouth rinses, and washes, while systemic fluorides are administered via lozenges, tablets, and liquid formulations. This literature work focuses on the specific challenges associated with fluoride supplement formulations and aims to shed light on potential setbacks. Among these challenges, poor patient compliance, especially in pediatric populations, and the associated risk of underdosing or overdosing, leading to fluorosis, stand out as significant concerns. If left unaddressed, these issues could compromise the efficacy of one of the most effective caries prevention methods available. The primary objective of this study is to explore advancements in fluoride supplement formulations, with a particular emphasis on addressing the identified challenges, especially for pediatric and geriatric patients. By devising improved formulations tailored to the unique needs of these populations, we aim to mitigate compliance issues and minimize the associated risk factors, thereby strengthening the effectiveness of dental caries prevention strategies. This research endeavors to contribute valuable insights to the field of oral healthcare and pharmaceutical development, ultimately promoting better oral health outcomes for individuals of all ages.