A case of eosinophilic gastroenteritis developed during administration of nivolumab for a patient with platinum-resistant head and neck cancer

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
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引用次数: 0

Abstract

Eosinophilic gastroenteritis (EGE) is an inflammatory disease that causes symptoms related to dysfunction owing to the high infiltration of eosinophils into the gastrointestinal tissue. We report a case of EGE that developed after severe eosinophilia induced by nivolumab administration. A 53-year-old woman was diagnosed with recurrent neck lymph node metastasis of right tongue cancer and was referred to our hospital for chemotherapy. After the administration of 12 courses of nivolumab, grade 2 diarrhea was observed, and contrast-enhanced computed tomography (CT) revealed intestinal wall edema and stenosis of the small intestine. Symptoms improved with fasting, discontinuation of nivolumab, and administration of a proton pump inhibitor. Biopsy performed using a colon fiberscope revealed EGE. After resuming nivolumab and administering three courses, positron emission tomography/CT confirmed a complete response to the metastatic lesion, and nivolumab was discontinued. After discontinuation, mild eosinophilia persisted, but abdominal symptoms, such as diarrhea, did not recur. No signs of recurrence or metastasis were observed after two years.

一例嗜酸性粒细胞性肠胃炎病例,患者在使用尼伐单抗治疗铂类耐药头颈癌期间发病
嗜酸性粒细胞性胃肠炎(EGE)是一种炎症性疾病,由于嗜酸性粒细胞大量浸润胃肠道组织而引起功能障碍相关症状。我们报告了一例因服用 nivolumab 而诱发严重嗜酸性粒细胞增多的 EGE 病例。一名 53 岁的女性被诊断为右舌癌颈部淋巴结复发转移,并被转诊至我院接受化疗。在接受了 12 个疗程的 nivolumab 治疗后,患者出现 2 级腹泻,对比增强计算机断层扫描(CT)显示肠壁水肿和小肠狭窄。禁食、停用 nivolumab 和服用质子泵抑制剂后,症状有所改善。使用结肠纤维镜进行的活组织检查发现了 EGE。在恢复使用尼妥珠单抗并服用三个疗程后,正电子发射断层扫描/CT 证实转移病灶完全反应,于是停用尼妥珠单抗。停药后,轻度嗜酸性粒细胞增多持续存在,但腹泻等腹部症状没有复发。两年后未发现复发或转移迹象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
129
审稿时长
83 days
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