The impact of deep venous thrombosis on 90 day mortality in chronic obstructive pulmonary disease patients presenting with pulmonary embolism

IF 2.2 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research Pub Date : 2024-02-15 DOI:10.1016/j.resmer.2024.101090

Sinem Nedime Sökücü , Celal Satıcı , Fatma Tokgöz Akyıl , Nurdan Şimşek Veske , Fatma Elif Koçal , Seda Tural Önür , Cengiz Özdemir

{"title":"The impact of deep venous thrombosis on 90 day mortality in chronic obstructive pulmonary disease patients presenting with pulmonary embolism","authors":"Sinem Nedime Sökücü , Celal Satıcı , Fatma Tokgöz Akyıl , Nurdan Şimşek Veske , Fatma Elif Koçal , Seda Tural Önür , Cengiz Özdemir","doi":"10.1016/j.resmer.2024.101090","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>There are a limited number of studies investigating the effect of deep venous thrombosis (DVT) in patients presenting with both pulmonary embolism and chronic obstructive pulmonary disease. The aim of this study is to investigate the prevalence and prognostic significance of DVT in patients with PE-COPD.</p></div><div><h3>Methods</h3><p>COPD patients admitted with a diagnosis of PE to our tertiary hospital between January 2016 and January 2021 were retrospectively evaluated with an electronic hospital database. Univariate and multivariate Cox regression analyses were performed to reveal independent prognostic factors.</p></div><div><h3>Results</h3><p>Two hundred thirty-three patients (mean age 65.1 ± 12.2, 158 men (67.5 %)) were included. DVT was present at the time of diagnosis in 45 (19.31 %) of the patients. Patients with DVT tend to have more comorbidities, central pulmonary embolism, higher CRP and <span>d</span>-dimer levels, and SPESI score (<em>p</em><0.05). After performing multivariate analyses, the presence of DVT (HR=3.48, CI: 1.02- 11.88, <em>p</em> = 0.046), ischemic heart disease (HR=3.82, CI: 1.38- 10.80, <em>p</em> = 0.01), and malignancy (HR=4.85, CI: 1.53- 15.41, <em>p</em> = 0.007) were found to be independent factors in predicting 90-day mortality.</p></div><div><h3>Conclusions</h3><p>In PE-COPD patients, co-existing DVT may predict a worse outcome.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"85 ","pages":"Article 101090"},"PeriodicalIF":2.2000,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Medicine and Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590041224000072","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Background

There are a limited number of studies investigating the effect of deep venous thrombosis (DVT) in patients presenting with both pulmonary embolism and chronic obstructive pulmonary disease. The aim of this study is to investigate the prevalence and prognostic significance of DVT in patients with PE-COPD.

Methods

COPD patients admitted with a diagnosis of PE to our tertiary hospital between January 2016 and January 2021 were retrospectively evaluated with an electronic hospital database. Univariate and multivariate Cox regression analyses were performed to reveal independent prognostic factors.

Results

Two hundred thirty-three patients (mean age 65.1 ± 12.2, 158 men (67.5 %)) were included. DVT was present at the time of diagnosis in 45 (19.31 %) of the patients. Patients with DVT tend to have more comorbidities, central pulmonary embolism, higher CRP and d-dimer levels, and SPESI score (p<0.05). After performing multivariate analyses, the presence of DVT (HR=3.48, CI: 1.02- 11.88, p = 0.046), ischemic heart disease (HR=3.82, CI: 1.38- 10.80, p = 0.01), and malignancy (HR=4.85, CI: 1.53- 15.41, p = 0.007) were found to be independent factors in predicting 90-day mortality.

Conclusions

In PE-COPD patients, co-existing DVT may predict a worse outcome.

查看原文本刊更多论文

深静脉血栓对慢性阻塞性肺病肺栓塞患者 90 天死亡率的影响

背景对同时患有肺栓塞和慢性阻塞性肺疾病的患者深静脉血栓形成（DVT）的影响进行调查的研究数量有限。本研究旨在探讨深静脉血栓在 PE-COPD 患者中的发病率和预后意义。方法利用医院电子数据库对 2016 年 1 月至 2021 年 1 月期间在本院三级医院住院并诊断为 PE 的 COPD 患者进行回顾性评估。结果共纳入 233 名患者（平均年龄 65.1 ± 12.2 岁，158 名男性（67.5%））。45名患者（19.31%）在诊断时存在深静脉血栓。深静脉血栓患者往往有更多的合并症、中心性肺栓塞、更高的 CRP 和 d-二聚体水平以及 SPESI 评分（p<0.05）。进行多变量分析后发现，存在深静脉血栓（HR=3.48，CI：1.02- 11.88，P=0.046）、缺血性心脏病（HR=3.82，CI：1.38- 10.80，P=0.01）和恶性肿瘤（HR=4.85，CI：1.53- 15.41，P=0.007）是预测 90 天死亡率的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊