Structural engineering of polyurethanes for biomedical applications

IF 26 1区化学 Q1 POLYMER SCIENCE

Progress in Polymer Science Pub Date : 2024-02-13 DOI:10.1016/j.progpolymsci.2024.101803

Haoran Wang, Tong Li, Jia Li, Ruohong Zhao, Ao Ding, Fu-Jian Xu

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Abstract

Polyurethane, a synthetic polymer distinguished by its urethane (carbamate, -NHCOO-) and/or urea (-NHCONH-) linkages, has been applied in various industries since its discovery in 1937 by Bayer and colleagues. The successful in vivo use of segmented multiblock thermoplastic polyurethane in 1967 marked the beginning of its development for biomedical applications. Over the past few decades, research on polyurethane biomaterials has evolved from focusing on biostable to biodegradable forms, exploring multifunctionality and application in areas like functional medical devices, tissue engineering scaffolds, drug delivery systems, etc.

This review aims to summarize the recent advancements in engineering polyurethane structures for biomedical applications, presenting the main methods utilized in their preparation, biological functions, and their main biomedical applications. In addition, we proposed four general strategies for engineering polyurethane structures in the biomedical field, offering a structured methodology for researchers and engineers engaged in polyurethane biomaterials work. Concluding the review, we spotlight future development directions, emphasizing multifunctional programmable polyurethane, peptide-mimicking polyurethane, and poly (hydroxyl urethane).

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用于生物医学应用的聚氨酯结构工程学

聚氨酯是一种合成聚合物，以其氨基甲酸酯（-NHCOO-）和/或尿素（-NHCONH-）连接而闻名，自 1937 年由拜尔公司及其同事发现以来，已被广泛应用于各行各业。1967 年，分段式多嵌段热塑性聚氨酯在体内的成功应用标志着其生物医学应用开发的开端。在过去的几十年中，聚氨酯生物材料的研究已从生物稳定型发展到生物可降解型，并在功能性医疗器械、组织工程支架、药物输送系统等领域探索其多功能性和应用。本综述旨在总结生物医学应用聚氨酯结构工程方面的最新进展，介绍其主要制备方法、生物功能及其主要生物医学应用。此外，我们还提出了生物医学领域聚氨酯结构工程的四种一般策略，为从事聚氨酯生物材料工作的研究人员和工程师提供了结构化方法。在综述的最后，我们强调了多功能可编程聚氨酯、肽模拟聚氨酯和聚（羟基聚氨酯）的未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Polymer Science 化学-高分子科学

CiteScore

48.70

自引率

1.10%

发文量

审稿时长

38 days

期刊介绍： Progress in Polymer Science is a journal that publishes state-of-the-art overview articles in the field of polymer science and engineering. These articles are written by internationally recognized authorities in the discipline, making it a valuable resource for staying up-to-date with the latest developments in this rapidly growing field. The journal serves as a link between original articles, innovations published in patents, and the most current knowledge of technology. It covers a wide range of topics within the traditional fields of polymer science, including chemistry, physics, and engineering involving polymers. Additionally, it explores interdisciplinary developing fields such as functional and specialty polymers, biomaterials, polymers in drug delivery, polymers in electronic applications, composites, conducting polymers, liquid crystalline materials, and the interphases between polymers and ceramics. The journal also highlights new fabrication techniques that are making significant contributions to the field. The subject areas covered by Progress in Polymer Science include biomaterials, materials chemistry, organic chemistry, polymers and plastics, surfaces, coatings and films, and nanotechnology. The journal is indexed and abstracted in various databases, including Materials Science Citation Index, Chemical Abstracts, Engineering Index, Current Contents, FIZ Karlsruhe, Scopus, and INSPEC.