The morphomolecular features of cholangiocarcinoma in the personalised era

Diagnostic Histopathology Pub Date : 2024-02-04 DOI:10.1016/j.mpdhp.2024.01.004

Daniel T. Field, Guido Carpino, Michail Doukas, Timothy J. Kendall

引用次数: 0

Abstract

Cholangiocarcinoma is a group of diverse invasive malignancies arising along the biliary tract. The outcomes for patients with cholangiocarcinoma remain poor but an understanding of molecular aberrations and subsequent targeted therapies to these have opened up new treatment prospects. This review describes the clinical and morphological features and classifications of intrahepatic and perihilar cholangiocarcinoma in addition to laying out the related landscape of the molecular pathology within cholangiocarcinoma. The importance of both a high index of suspicion of cholangiocarcinoma and preserving tissue whilst reporting to access molecular testing and personalised treatment pathways is emphasised.

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个性化时代胆管癌的形态分子特征

胆管癌是一组沿胆道发生的多种侵袭性恶性肿瘤。胆管癌患者的预后仍然不佳，但对分子畸变的了解和随后的靶向治疗为其开辟了新的治疗前景。这篇综述描述了肝内胆管癌和肝周胆管癌的临床和形态特征及分类，此外还介绍了胆管癌分子病理学的相关情况。文中强调了高度怀疑胆管癌和保留组织的重要性，同时指出报告可用于分子检测和个性化治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.