First Report of a Novel Goose Adenovirus Outbreak in Lion Head Gooses in China

Transboundary and Emerging Diseases Pub Date : 2024-02-08 DOI:10.1155/2024/3980468

Rong-chang Liu, Minhua Sun, Qin Lan, Jiaxue Zhang, Qizhang Liang, Guanghua Fu, Ming Liao, Yu Huang

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Abstract

In April 2022, a novel Goose adenovirus (GoAdV) isolated from diseased Lion head gooses exhibiting swelling and hemorrhage of liver and kidney, accumulation of fluid in pericardial, in Fujian province of China. The GoAdV was propagated in goose embryo fibroblasts (GEFs), the morphological properties of the virions were studied by electron microscopy, and the full genome sequence was determined and analyzed. The results revealed that the infected cells became round and clustered like grapes, virions accumulated and were arranged in crystal lattice formations in the nucleus of GEFs with a diameter of ∼80 nm. The new isolate (named CH-FJZZ-202201) has a viral genome size of 43,480 bp and shared 96.69% sequence identity with GoAdV-4 (P29), representing the species Goose aviadenovirus A. Phylogenetic analysis showed that CH-FJZZ-202201 was in the same genetic evolutionary branch with the viruses of Aviadenovirus and was the closest relative to GoAdV-4 P29/Hungary. This is the first report of the GoAdV-4 outside of Hungary, indicating the reemergence of new AdV strains in China.

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中国首次报告狮头鹅爆发新型鹅腺病毒疫情

2022年4月，从福建省狮头鹅病例中分离到一种新型鹅腺病毒（GoAdV），表现为肝肾肿胀、出血、心包积液等症状。研究人员在鹅胚成纤维细胞（GEFs）中繁殖了GoAdV，用电子显微镜研究了病毒的形态特征，并测定和分析了病毒的全基因组序列。结果表明，被感染的细胞变得像葡萄一样圆而聚集，病毒在鹅胚成纤维细胞的细胞核内聚集并呈晶格状排列，直径∼80 nm。新分离株（命名为 CH-FJZZ-202201）的病毒基因组大小为 43,480 bp，与 GoAdV-4 (P29) 有 96.69% 的序列同一性，代表鹅禽流感病毒 A 种。系统进化分析表明，CH-FJZZ-202201 与禽流感病毒处于同一遗传进化分支，是 GoAdV-4 P29/Hungary 的近亲。这是首次在匈牙利境外发现GoAdV-4病毒，表明中国又出现了新的AdV毒株。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transboundary and Emerging Diseases

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