F. Iebba, Vera Elena Bottari, Fiorella Di Sora, M. Mallus, R. M. Manfredi, Francesco Prati
{"title":"Combined immunosuppressive treatment for giant cell myocarditis: a case report","authors":"F. Iebba, Vera Elena Bottari, Fiorella Di Sora, M. Mallus, R. M. Manfredi, Francesco Prati","doi":"10.4081/itjm.2024.1700","DOIUrl":null,"url":null,"abstract":"Giant cell myocarditis (GCM) is a rare and often fulminant autoimmune disease. The immune-mediated pathogenesis of GCM is also supported by animal models, association with other immunological diseases and therapeutic efficacy of immunosuppressive drugs. The diagnosis of GCM is based on endomyocardial biopsy. GCM is an orphan disease. Heart transplantation is effective but up to 25% of transplanted patients experience disease recurrence. Immunosuppressive drugs have been shown to be potential therapeutic agents for GCM. In the present case report, the prescription of cyclosporine, azathioprine and prednisone resulted in a rapid and prolonged remission in support of the role of a combined immunosuppressive regimen in improving the long-term prognosis of this cardiac pathology.","PeriodicalId":43715,"journal":{"name":"Italian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/itjm.2024.1700","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Giant cell myocarditis (GCM) is a rare and often fulminant autoimmune disease. The immune-mediated pathogenesis of GCM is also supported by animal models, association with other immunological diseases and therapeutic efficacy of immunosuppressive drugs. The diagnosis of GCM is based on endomyocardial biopsy. GCM is an orphan disease. Heart transplantation is effective but up to 25% of transplanted patients experience disease recurrence. Immunosuppressive drugs have been shown to be potential therapeutic agents for GCM. In the present case report, the prescription of cyclosporine, azathioprine and prednisone resulted in a rapid and prolonged remission in support of the role of a combined immunosuppressive regimen in improving the long-term prognosis of this cardiac pathology.