THE EFFECTIVENESS OF LEVOFLOXACIN 0.5% WITH POVIDONE IODINE 2.5% IN REDUCING CONJUNCTIVA BACTERIAL FLORA IN PRE INTRA OCULAR OPERATIVE

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI:10.35749/q09epw41

OKTA KURNIAWAN SAPUTRA

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Abstract

Abstract Introduction & Objectives : This study aims to compare the effectiveness of Levofloxacin ED 0.5% with Povidone iodine 2.5% in reducing normal bacterial flora of the conjunctiva in preoperative procedures. Methods : Clinical trials will be conducted in the inpatient ward on patients who will undergo intravitreal surgery at Mohammad Hoesin Hospital Palembang from May 2022-July 2022. Subjects were divided into two groups, which is Levofloxacin ED 0.5% and Povidone iodine 2.5% group. Before and after the fornices preparation, the number of bacterial colonies that grow will be counted and evaluated using bivariate analysis. Results : There were 32 samples that fulfilled the inclusion criteria. A significant decrease of conjunctival flora was observed in both groups (p value = 0.000). Comparison of the two groups’ decrease in conjunctival flora was not significant. There was a reduction of up to 100% in 11 samples (68.75%) of both intervention groups. Conclusion : The use of Levofloxacin 0.5% and Povidone iodine 2.5% was equally good in reducing the number of bacterial colonies in the conjunctiva.

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左氧氟沙星 0.5%和聚维酮碘 2.5%对减少眼内手术前结膜细菌群的有效性

摘要简介与目的：本研究旨在比较左氧氟沙星 ED 0.5%与聚维酮碘 2.5%在减少术前结膜正常细菌菌群方面的效果。方法：临床试验将于 2022 年 5 月至 2022 年 7 月在巴伦邦 Mohammad Hoesin 医院的住院病房进行，对象是即将接受玻璃体内手术的患者。受试者分为两组，即左氧氟沙星 ED 0.5%组和聚维酮碘 2.5%组。在制备穹窿前后，将对生长的细菌菌落数量进行计数，并使用双变量分析进行评估。结果：32 个样本符合纳入标准。两组的结膜菌群都明显减少（P 值 = 0.000）。两组结膜菌群减少量的比较差异不显著。两个干预组的 11 个样本（68.75%）的菌群减少率均高达 100%。结论：使用 0.5% 左氧氟沙星和 2.5% 聚维酮碘在减少结膜细菌菌落数量方面效果相同。

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Ophthalmologica Indonesiana

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