Herbal and dietary supplement induced liver injury leading to hepatitis‐associated severe aplastic anemia: A case report

JPGN reports Pub Date : 2024-02-12 DOI:10.1002/jpr3.12041
R. Mercedes, S. Harpavat, Paula M. Hertel, Ghadir Sasa, Susan Kirk, Kalyani Patel, K. Mysore
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Abstract

Herbal and dietary supplements (HDS) are a common etiology of drug induced liver injury and, specifically, Herbalife® supplements have been implicated. Hepatitis associated aplastic anemia (HAAA) is a rare and potentially fatal complication after acute hepatitis characterized by pancytopenia. While there have been rare cases of HDS leading to HAAA, no cases of Herbalife® induced liver injury leading to HAAA have been reported from this specific HDS. We report a unique case of severe aplastic anemia developing after sub‐fulminant liver failure associated with chronic HDS use. This case illustrates the importance of warning the public about HDS as their use continues to increase. It is not only important to recognize HDS as etiology, but also for healthcare providers to carefully monitor these patients after resolution of liver injury for the development of HAAA.
草药和膳食补充剂诱发肝损伤,导致肝炎相关性重型再生障碍性贫血:病例报告
草药和膳食补充剂(HDS)是药物性肝损伤的常见病因,特别是康宝莱®保健品与此有牵连。肝炎相关性再生障碍性贫血(HAAA)是急性肝炎后的一种罕见且可能致命的并发症,其特征是全血细胞减少。雖然有罕見的HDS導致再生不良性貧血的病例,但尚未有康寶萊®誘發肝損傷導致再生不良性貧血的病例報告。我們報告了一例因長期服用HDS而導致肝衰竭的病例。该病例说明,随着 HDS 使用量的不断增加,向公众发出有关 HDS 的警告非常重要。医护人员不仅要认识到 HDS 是病因,还要在肝损伤缓解后仔细监测这些患者,以防发生 HAAA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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