COVID-19 vaccine hesitancy in KwaZulu-Natal, South Africa: A survey of unvaccinated adults

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
T. Gengiah, Donavan C. Naidoo, Nomcebo Maduma, Saien Govender, Sherishka Dhindayal, Lara Lewis
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Abstract

Background: Concerns and misconceptions surrounding coronavirus disease 2019 (COVID-19) vaccines may account for vaccine hesitancy and low uptake.Aim: To determine prevalence of COVID-19 vaccine hesitancy, vaccine-related misconceptions, and predictors of vaccine hesitancy among South Africans.Setting: Community setting in five districts in KwaZulu- Natal province.Methods: Between August 20, 2021, and September 27, 2021, we conducted a cross-sectional survey, interviewing 300 unvaccinated adults amid the national vaccination campaign. Predictors of hesitancy were identified through multivariable logistic regression analysis.Results: Participants had a median age of 29 years (IQR: 23–39), 86.7% were Black African, 63.2% were male, 53.3% resided in rural communities, and 59.3% (95% CI: 53.8% – 64.9%) were classified as vaccine hesitant. The primary reason for not vaccinating was a lack of trust in the vaccine (62.1%). Factors associated with reduced vaccine hesitancy included age (participants aged 35–49 years: OR: 0.28, 95% CI: 0.18–0.64, p = 0.003; participants over 50 years: OR: 0.18, 95% CI: 0.07–0.47, p = 0.0004), previous COVID-19 infection (OR: 0.31, 95% CI: 0.11–0.87, p = 0.03), and receiving vaccine information from healthcare workers (OR: 0.32, 95% CI: 0.10–1.0, p = 0.05). Unemployed (OR: 2.14, 95% CI: 1.1–4.2, p = 0.03) and self-employed individuals (OR: 2.98, 95% CI: 1.27–7.02, p = 0.01) were more likely to be vaccine hesitant.Conclusion: COVID-19 vaccine hesitancy rates are high in KwaZulu-Natal. Uptake could be enhanced by healthcare workers leading information campaigns with messages targeting younger individuals, the unemployed, and the self-employed.Contribution: This survey provides evidence to improve COVID-19 vaccination uptake in South Africa.
南非夸祖鲁-纳塔尔省对 COVID-19 疫苗的犹豫态度:对未接种疫苗成年人的调查
背景:目的:确定南非人对2019年冠状病毒病(COVID-19)疫苗犹豫不决的普遍程度、与疫苗相关的误解以及疫苗犹豫不决的预测因素:环境:夸祖鲁-纳塔尔省五个地区的社区环境:2021年8月20日至2021年9月27日期间,我们进行了一次横断面调查,在全国疫苗接种活动中采访了300名未接种疫苗的成年人。通过多变量逻辑回归分析确定了犹豫不决的预测因素:参与者的年龄中位数为 29 岁(IQR:23-39),86.7% 为非洲黑人,63.2% 为男性,53.3% 居住在农村社区,59.3%(95% CI:53.8% - 64.9%)被归类为疫苗犹豫不决者。不接种的主要原因是对疫苗缺乏信任(62.1%)。与疫苗接种犹豫减少相关的因素包括年龄(35-49 岁的参与者:OR:0.28,95% CI:0.18-0.64,p = 0.003;50 岁以上的参与者:OR:0.18,95% CI:0.07-0.47,p = 0.0004),曾感染 COVID-19(OR:0.31,95% CI:0.11-0.87,p = 0.03),从医护人员处获得疫苗信息(OR:0.32,95% CI:0.10-1.0,p = 0.05)。失业者(OR:2.14,95% CI:1.1-4.2,p = 0.03)和自营职业者(OR:2.98,95% CI:1.27-7.02,p = 0.01)更有可能对疫苗犹豫不决:结论:COVID-19疫苗在夸祖鲁-纳塔尔省的犹豫率很高。医护人员可以针对年轻人、失业者和自营职业者开展宣传活动,从而提高疫苗的接种率:贡献:这项调查为提高南非的 COVID-19 疫苗接种率提供了证据。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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