MATHEMATICAL MODEL FOR SYSTEM DYNAMICS OF (Ca2+) AND DOPAMINE IN A FIBROBLAST CELL

IF 1.3 4区数学 Q3 BIOLOGY

Journal of Biological Systems Pub Date : 2024-02-01 DOI:10.1142/s0218339024500177

Ankit Kothiya, N. Adlakha

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引用次数: 0

Abstract

Fibroblasts significantly affect wound healing, cancer progression and development. Disturbances in the calcium [Formula: see text] and dopamine [Formula: see text] dynamics leads to fibrotic disorders like cancer and fibrosis. Calcium signaling is required for [Formula: see text] concentrations in fibroblasts. Alteration in the many processes of [Formula: see text] kinetics can disturb [Formula: see text] regulation in fibroblast cells. No model has been reported till date for the study of spatiotemporal relationships of [Formula: see text] with calcium signaling in fibroblasts. A model is provided here to study the dynamic relationship of [Formula: see text] regulation with calcium signaling in a fibroblast cell. Finite element and Crank–Nicholson techniques are employed for numerical simulation. The numerical results provide insights into the buffer, source influx, and diffusion effects on the spatiotemporal dynamics of [Formula: see text] and [Formula: see text] in a fibroblast. Disturbances in the constitutive processes in the system dynamics of [Formula: see text] and [Formula: see text] can cause fibrotic diseases such as fibrosis and cancer in various organs.

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纤维泡沫细胞中（Ca2+）和多巴胺的系统动力学数学模型

成纤维细胞对伤口愈合、癌症进展和发展有着重要影响。钙[计算公式：见正文]和多巴胺[计算公式：见正文]动态紊乱会导致癌症和纤维化等纤维化疾病。成纤维细胞中的[公式：见正文]浓度需要钙信号传递。改变[公式：见正文]动力学的许多过程会扰乱成纤维细胞中的[公式：见正文]调节。迄今为止，还没有研究成纤维细胞中[公式：见正文]与钙信号转导时空关系的模型。本文提供了一个模型来研究成纤维细胞中[公式：见正文]调控与钙信号传导的动态关系。数值模拟采用了有限元和 Crank-Nicholson 技术。数值结果深入揭示了缓冲、源流入和扩散对成纤维细胞中[公式：见正文]和[公式：见正文]时空动态的影响。公式：见正文]和[公式：见正文]系统动力学组成过程的紊乱可导致纤维化疾病，如各种器官的纤维化和癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Systems 生物-生物学

CiteScore

2.80

自引率

12.50%

发文量

审稿时长

1 months

期刊介绍： The Journal of Biological Systems is published quarterly. The goal of the Journal is to promote interdisciplinary approaches in Biology and in Medicine, and the study of biological situations with a variety of tools, including mathematical and general systems methods. The Journal solicits original research papers and survey articles in areas that include (but are not limited to): Complex systems studies; isomorphies; nonlinear dynamics; entropy; mathematical tools and systems theories with applications in Biology and Medicine. Interdisciplinary approaches in Biology and Medicine; transfer of methods from one discipline to another; integration of biological levels, from atomic to molecular, macromolecular, cellular, and organic levels; animal biology; plant biology. Environmental studies; relationships between individuals, populations, communities and ecosystems; bioeconomics, management of renewable resources; hierarchy theory; integration of spatial and time scales. Evolutionary biology; co-evolutions; genetics and evolution; branching processes and phyllotaxis. Medical systems; physiology; cardiac modeling; computer models in Medicine; cancer research; epidemiology. Numerical simulations and computations; numerical study and analysis of biological data. Epistemology; history of science. The journal will also publish book reviews.