The Value of Near-Infrared Multifunctional Nanoprobe Combined with Artificial Intelligence Microsensor Technology in Molecular Diagnosis for Gastric Cancer

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-02-01 DOI:10.1166/jbn.2024.3769

Qiang Sun, Jun Yao, Shuxun Wei, Xinxing Li, Weijun Wang

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引用次数: 0

Abstract

Since the symptoms of early gastric cancer patients are not obvious, the majority of new gastric cancer cases are progressive gastric cancer every year. In this paper, we applied nanomedicine technology to design and prepare multifunctional nanoparticles for the diagnosis and treatment of gastric cancer. Through targeted imaging of gastric cancer, combined with phototherapy and the prepared nanoprobes are applied to the ectopic transplantation tumor model of gastric cancer. Meanwhile, a fluorescent microsensor based on graphene oxide and deoxyribonuclease is constructed in order to realize the rapid detection of gastric cancer exosomes. The near-infrared multifunctional nanoprobe is combined with artificial intelligence microsensor technology and applied to the molecular diagnosis of gastric cancer. The results shows that the P-P-I-M+ laser irradiation group has the highest fluorescence intensity and its average fluorescence intensity is 2.04 times higher than that of the P-P-I+ laser irradiation group. The relative cell viability of P-P-M+ laser irradiation group, P-P-I+ laser irradiation group and P-P-I-M+ laser irradiation group are 62.5%, 41.9% and 19.3%, respectively. Therefore, the method in this paper can reduce the non-specific toxicity to other organs as well as exert the effect of combining the diagnosis and treatment of gastric cancer.

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近红外多功能纳米探针与人工智能微传感器技术在胃癌分子诊断中的应用价值

由于早期胃癌患者症状不明显，每年新增的胃癌病例以进展期胃癌居多。本文应用纳米医学技术设计制备了多功能纳米探针，用于胃癌的诊断和治疗。通过胃癌靶向成像，结合光疗，将制备的纳米探针应用于胃癌异位移植肿瘤模型。同时，构建了基于氧化石墨烯和脱氧核糖核酸酶的荧光微传感器，以实现对胃癌外泌体的快速检测。将近红外多功能纳米探针与人工智能微传感器技术相结合，应用于胃癌的分子诊断。结果表明，P-P-I-M+激光照射组的荧光强度最高，其平均荧光强度是P-P-I+激光照射组的2.04倍。P-P-M+激光照射组、P-P-I+激光照射组和P-P-I-M+激光照射组的相对细胞活力分别为62.5%、41.9%和19.3%。因此，本文的方法既能减少对其他器官的非特异性毒性，又能发挥胃癌诊断与治疗相结合的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.