Sangpil Kim, Gaeun Park, Dohyun Kim, Md. Sajid Hasan, Chaelyeong Lim, Min-Seok Seu, Ja-Hyoung Ryu
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引用次数: 0
Abstract
Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition-mediated interactions. The introduction of artificial structures has garnered substantial interest in modulating cellular functions via activation/inhibition interactions with biomacromolecules. However, the cellular uptake of these high-molecular-weight structures may limit their performance. Recently, intracellular chemical-reaction-induced self-assembly has emerged as a promising strategy for generating in situ nanostructures with biofunctionalities for interacting with biomacromolecules. This approach addresses the challenge of synthetic reactions occurring in complex intracellular environments by utilizing diverse chemical reactions that respond to endogenous and exogenous stimuli. This review provides an overview of the latest advancements in intracellular chemical-reaction-induced self-assembly techniques. It focuses on their responsiveness to specific endogenous conditions, such as redox environments and overexpressed enzymes. Additionally, the initiation of chemical reactions through exogenous stimuli, including chemical reagents and irradiation is explored. Polymerization-induced hydrophobicity is highlighted, leading to self-assembly into micro-/nanostructures. These processes contribute to the in situ construction of synthetic materials with diverse morphologies, offering versatile functionalities for biological applications.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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