Fabrication and In Vitro Biocompatibility Evaluation of Zr48Cu36Al9Ag7 Amorphous Alloy Scalpel

IF 3.3 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Metals and Materials International Pub Date : 2024-02-06 DOI:10.1007/s12540-023-01622-4

K. P. Shinde, P. K. Chaturvedi, J. S. Oh, J. N. Park, K. Choi, D. Shin, J. Oh, S. Yi, K. Ku, S. Lee, C. H. Chung, Woo Yoon Park, Joon Sik Park

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Abstract

Zirconium based amorphous alloys are suitable for biomedical applications because of their excellent corrosion resistance and biocompatibility. In this study, Zr₄₈Cu₃₆Al₉Ag₇ amorphous alloy was fabricated by arc melting and ingot converted into the plate-shaped amorphous alloy by the suction method in a water cooled copper mold. Scalpels of the amorphous alloy were fabricated by using the polishing method. The X-ray diffraction and differential scanning calorimetry confirmed the amorphous nature of the Zr₄₈Cu₃₆Al₉Ag₇ alloy. Elemental confirmation of the amorphous alloy was confirmed with X-ray photoelectron spectroscopy analysis. The hardness of amorphous alloy was compared with a commercial stainless steel scalpel. The observed corrosion potentials of the stainless steel scalpel and Zr₄₈Cu₃₆Al₉Ag₇ amorphous scalpel were − 0.6 V and − 0.4 V, respectively which confirms that the corrosion resistance of the amorphous alloy is better than stainless steel. The biomedical application of the Zr₄₈Cu₃₆Al₉Ag₇ amorphous alloy scalpel is supported by a comparative study that examined in vitro cytotoxicity, cell viability, and wound healing tests and compared it with the standard stainless steel scalpel.

Graphical Abstract

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Zr48Cu36Al9Ag7 非晶合金手术刀的制造和体外生物相容性评估

锆基非晶合金具有优异的耐腐蚀性和生物相容性，因此适用于生物医学应用。本研究采用电弧熔炼法制造了 Zr48Cu36Al9Ag7 非晶合金，并在水冷铜模中采用抽吸法将铸锭转化为板状非晶合金。非晶合金的薄片是用抛光法制造的。X 射线衍射和差示扫描量热证实了 Zr48Cu36Al9Ag7 合金的非晶体性质。X 射线光电子能谱分析证实了非晶态合金的元素确认。非晶态合金的硬度与商用不锈钢手术刀进行了比较。观察到不锈钢手术刀和 Zr48Cu36Al9Ag7 非晶手术刀的腐蚀电位分别为 - 0.6 V 和 - 0.4 V，这证实了非晶合金的耐腐蚀性优于不锈钢。一项比较研究对 Zr48Cu36Al9Ag7 非晶合金手术刀的体外细胞毒性、细胞活力和伤口愈合测试进行了检验，并将其与标准不锈钢手术刀进行了比较，从而支持了 Zr48Cu36Al9Ag7 非晶合金手术刀的生物医学应用。

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来源期刊

Metals and Materials International 工程技术-材料科学：综合

CiteScore

7.10

自引率

8.60%

发文量

197

审稿时长

3.7 months

期刊介绍： Metals and Materials International publishes original papers and occasional critical reviews on all aspects of research and technology in materials engineering: physical metallurgy, materials science, and processing of metals and other materials. Emphasis is placed on those aspects of the science of materials that are concerned with the relationships among the processing, structure and properties (mechanical, chemical, electrical, electrochemical, magnetic and optical) of materials. Aspects of processing include the melting, casting, and fabrication with the thermodynamics, kinetics and modeling.