Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Neuropathology and Applied Neurobiology Pub Date : 2024-02-05 DOI:10.1111/nan.12965

Rebecca Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C. Lau, James A. R. Nicoll, Clive Holmes, Delphine Boche

引用次数: 0

Abstract

In Alzheimer's disease (AD), the locus coeruleus (LC) undergoes early and extensive neuronal loss, preceded by abnormal intracellular tau aggregation, decades before the onset of clinical disease. Neuromelanin-sensitive MRI has been proposed as a method to image these changes during life. Surprisingly, human post-mortem studies have not examined how changes in LC during the course of the disease relate to cerebral pathology following the loss of the LC projection to the cortex.

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阿尔茨海默氏症病程中神经节的变化及其与大脑皮层病理学的关系

在阿尔茨海默病（AD）患者中，局部小脑（LC）在临床发病前数十年就会出现早期和广泛的神经元缺失，并伴有细胞内 tau 的异常聚集。神经褪黑素敏感核磁共振成像（MRI）被认为是对生命过程中这些变化进行成像的一种方法。令人惊讶的是，人类的死后研究并未考察 LC 在发病过程中的变化与 LC 向皮层投射消失后大脑病理学的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropathology and Applied Neurobiology 医学-病理学

CiteScore

8.20

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Neuropathology and Applied Neurobiology is an international journal for the publication of original papers, both clinical and experimental, on problems and pathological processes in neuropathology and muscle disease. Established in 1974, this reputable and well respected journal is an international journal sponsored by the British Neuropathological Society, one of the world leading societies for Neuropathology, pioneering research and scientific endeavour with a global membership base. Additionally members of the British Neuropathological Society get 50% off the cost of print colour on acceptance of their article.