Intermolecular Interactions of Cefotaxime with Sodium Alginate Biopolymer in Aqueous Solutions

IF 0.6 4区化学 Q4 CHEMISTRY, APPLIED

Russian Journal of Applied Chemistry Pub Date : 2024-02-13 DOI:10.1134/S1070427223040043

G. M. Mirgaleev, S. V. Shilova, V. P. Barabanov

引用次数: 0

Abstract

The complexation of cefotaxime with an anionic polysaccharide, sodium alginate, in aqueous solutions with different pH values was studied by conductometry and by UV and IR spectroscopy. The compositions and stability constants of the complexes were determined. At pH 2.0, 5.6, and 7.2, the composition of the complex of cefotaxime with alginate corresponds to the [cefotaxime] : [alginate] molar ratio of 4.0 : 1.0, 2.3 : 1.0, and 1.0 : 1.0, respectively. The cefotaxime–alginate complex is most stable in strongly acidic media.

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水溶液中头孢他啶与海藻酸钠生物聚合物的分子间相互作用

摘要通过电导率测定法以及紫外和红外光谱法研究了头孢他啶与阴离子多糖海藻酸钠在不同 pH 值水溶液中的络合反应。测定了复合物的组成和稳定常数。在 pH 值为 2.0、5.6 和 7.2 时，头孢噻肟与海藻酸盐复合物的组成对应于[头孢噻肟]：[海藻酸盐]摩尔比为 4.0 : 1.0、2.3 ：分别为 4.0 : 1.0、2.3 : 1.0 和 1.0 : 1.0。头孢他啶-海藻酸盐复合物在强酸性介质中最为稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of Applied Chemistry 化学-应用化学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

2-4 weeks

期刊介绍： Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.