Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

IF 1.4 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochimica Acta Pub Date : 2024-02-14 DOI:10.1515/ract-2023-0234

Aulia Arivin Billah, Kukuh Eka Prasetya, Fany Triyatna, Daya Agung Sarwono, Abidin Abidin, Fernanto Rindiyantono, Maiyesni Maiyesni, Miftakul Munir, Indra Saptiama, Rien Ritawidya, Agustino Zulys

引用次数: 0

Abstract

The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

查看原文本刊更多论文

α-羟基异丁酸辅助固液色谱法分离中子辐照天然镱中的镥-177

利用柱层析分离法，从中子激活的天然镱（Yb）中开发了无载体添加镥-177（177Lu）的生产方法。Dowex W50 X8 树脂以及α-羟基异丁酸（α-HIBA）和盐酸（HCl）的组合分别用作柱填料和洗脱剂。当盐酸的浓度为 0.25 M 时，可提高 177Lu 和镱的解吸和分离效果，而最佳的 α-HIBA 浓度为 0.15 M，因此 177Lu 的产量为 81.19 %，杂质较少（175镱：9.28 %，169镱：2.09 %）。尽管如此，要想显著提高 177Lu 的比活度，必须使用富集的 176Yb 靶件进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Radiochimica Acta 化学-核科学技术

CiteScore

2.90

自引率

16.70%

发文量

审稿时长

6 months

期刊介绍： Radiochimica Acta publishes manuscripts encompassing chemical aspects of nuclear science and technology.