Iron and Molybdenum Content in the Immune-Privileged Organs of Rats upon the Administration of Nanocluster Porous Spherical Keplerate-Type Polyoxometalate {Mo72Fe30}

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2024-02-08 DOI:10.1134/S2635167623601079

A. A. Ostroushko, I. F. Gette, I. G. Danilova, S. Yu. Medvedeva, E. V. Koveza, M. A. Andreeva, M. V. Morozova, M. O. Tonkushina

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Abstract

Studies of the concentration of iron and molybdenum in the immune-privileged organs of rats without a pathology and after simulating posthemorrhagic anemia, which received intramuscular injections of Keplerate-type nanocluster porous spherical polyoxometalate (POM) {Mo₇₂Fe₃₀}, are conducted. The blood–testis barrier is the most resistant to the penetration of the components of POM, the blood–brain and blood–ocular barriers possess a lower resistance (accumulation of iron after 30 injections of POM), and the blood–thymus barrier is the least resistant. The borrowing of iron from immune-privileged organs such as the brain, eyeballs, and thymus occurs in the early stages (1 to 7 days) of posthemorrhagic anemia. Posthemorrhagic anemia decreases the resistance of the blood–brain barrier and is accompanied by the excessive accumulation of iron after seven injections of POM.

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施用纳米多孔球形开普勒型多氧金属酸盐 {Mo72Fe30} 后大鼠免疫器官中的铁和钼含量

摘要对肌肉注射开普勒型纳米簇多孔球形聚氧化金属锰（POM）{Mo72Fe30}的无病理大鼠和模拟失血性贫血后大鼠免疫优势器官中铁和钼的浓度进行了研究。血睾屏障对 POM 成分渗透的抵抗力最强，血脑屏障和血眼屏障的抵抗力较低（注射 30 次 POM 后铁的积累），而血胸膜屏障的抵抗力最弱。从脑、眼球和胸腺等免疫优势器官借铁发生在失血性贫血后的早期阶段（1 至 7 天）。出血后贫血会降低血脑屏障的抵抗力，并在注射七次 POM 后伴随铁的过度积累。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.