Identification of Detonation-Nanodiamond Particles and Detection of Their Localization in Human Macrophages and Mouse Lungs

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2023-12-01 DOI:10.1134/s2635167623601031

引用次数: 0

Abstract

Nanodiamonds modified with functional groups are obtained for targeted drug delivery. A set of methods for identifying nanodiamonds in biological material is determined and their localization in human macrophages and mouse lung cells is identified. It is shown that seven days after introduction into the mouse lungs, nanodiamonds are internalized by endotheliocytes and interstitial macrophages. Both in the human macrophage culture and in the lung cells, nanodiamonds are localized in phagosomes/phagolysosomes. The nanodiamonds do not cause pathological changes in human macrophages and mouse lung cells. The results obtained lead us to consider nanodiamonds as a promising carrier platform for drug delivery, first and foremost to macrophages of the interstitium of the respiratory portion of the lung, which is relevant in such a disease as tuberculosis.

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鉴定爆破纳米金刚石微粒并检测其在人类巨噬细胞和小鼠肺部的定位情况

摘要获得了经功能基团修饰的纳米金刚石，用于靶向给药。确定了一套识别生物材料中纳米金刚石的方法，并确定了它们在人巨噬细胞和小鼠肺细胞中的定位。研究表明，纳米金刚石进入小鼠肺部七天后，就会被内皮细胞和间质巨噬细胞内化。在人巨噬细胞培养物和肺细胞中，纳米金刚石都定位于吞噬体/吞噬溶酶体中。纳米金刚石不会导致人类巨噬细胞和小鼠肺细胞发生病理变化。这些结果使我们认为纳米金刚石是一种很有前景的载体平台，可用于给药，首先是给肺部呼吸道间质的巨噬细胞给药，这与肺结核等疾病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.

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