Intact modulation of response vigor in major depressive disorder

IF 1.7 3区 心理学 Q3 PSYCHOLOGY, EXPERIMENTAL
Shirel Bakbani-Elkayam, Tohar Dolev-Amit, Eitan Hemed, Sigal Zilcha-Mano, Baruch Eitam
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Abstract

Blunted motivation is a core symptom of Major Depressive Disorder (MDD). Although the empirical picture is mixed, cognitive processes that can be collectively referred to as reward processing have been found to be consistently muted in MDD; most notably, reward sensitivity and reinforcement learning. Works on the modulation of response vigor in individuals with MDD have examined various types of reward, but recent research has shown that in the general population, response vigor is not modulated by type of reward on tasks that are highly similar to those used in these experiments. The present study implemented a form of non-reward related reinforcement which has repeatedly been shown to modulate response vigor in the general population. It investigated whether modulation of response vigor by this type of reinforcement would be effective in individuals with MDD. Clinically depressed individuals (N = 121; 76 post-exclusion) engaged in a task in which their responses led to predictable and immediate sensorimotor effects, or no such effects. Response vigor increased when responses led to sensorimotor effects, which was comparable to the increase found in the general population. These findings support the utility of isolating the computations leading to different reinforcement types and suggest that motivational deficits in MDD may be specific to the type of reward (i.e., hedonically or otherwise explicitly desired stimuli). These results contribute to the literature by suggesting that the reinforcement from sensorimotor predictability stems from processes devolved to motor control, whereas reinforcement from rewards may depend on more general-purpose processes.

Abstract Image

重度抑郁障碍中反应活力的完整调节
动机减退是重度抑郁症(MDD)的一个核心症状。虽然实证研究结果不一,但人们发现,在 MDD 患者中,统称为奖赏加工的认知过程一直处于失调状态;其中最明显的是奖赏敏感性和强化学习。有关 MDD 患者反应强度调节的研究已经对各种类型的奖赏进行了研究,但最近的研究表明,在与这些实验高度相似的任务中,普通人群的反应强度并不受奖赏类型的调节。本研究采用了一种与奖励无关的强化方式,这种强化方式在普通人群中被反复证明可以调节反应强度。本研究调查了这种强化形式对反应强度的调节是否对患有精神抑郁症的人有效。临床抑郁症患者(121 人;76 人在排除后)参与了一项任务,在这项任务中,他们的反应会导致可预测的即时感官运动效应或无此类效应。当反应导致感觉运动效应时,反应强度会增加,这与在普通人群中发现的增幅相当。这些发现支持了将导致不同强化类型的计算分离出来的实用性,并表明 MDD 的动机缺陷可能与奖励类型(即享乐或其他明确期望的刺激)有关。这些结果表明,感知运动可预测性带来的强化源于下放到运动控制的过程,而奖励带来的强化可能依赖于更通用的过程,从而为相关文献做出了贡献。
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来源期刊
CiteScore
5.40
自引率
4.20%
发文量
69
期刊介绍: Motivation and Emotion publishes articles on human motivational and emotional phenomena that make theoretical advances by linking empirical findings to underlying processes. Submissions should focus on key problems in motivation and emotion, and, if using non-human participants, should contribute to theories concerning human behavior.  Articles should be explanatory rather than merely descriptive, providing the data necessary to understand the origins of motivation and emotion, to explicate why, how, and under what conditions motivational and emotional states change, and to document that these processes are important to human functioning.A range of methodological approaches are welcome, with methodological rigor as the key criterion.  Manuscripts that rely exclusively on self-report data are appropriate, but published articles tend to be those that rely on objective measures (e.g., behavioral observations, psychophysiological responses, reaction times, brain activity, and performance or achievement indicators) either singly or combination with self-report data.The journal generally does not publish scale development and validation articles.  However, it is open to articles that focus on the post-validation contribution that a new measure can make.  Scale development and validation work therefore may be submitted if it is used as a necessary prerequisite to follow-up studies that demonstrate the importance of the new scale in making a theoretical advance.
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