Efficacy evaluation of standardized Boswellia serrata extract (AflapinⓇ) in osteoarthritis: A systematic review and sub-group meta-analysis study

IF 1.9 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Vishal Dubey, Dharmeshkumar Kheni, Varun Sureja
{"title":"Efficacy evaluation of standardized Boswellia serrata extract (AflapinⓇ) in osteoarthritis: A systematic review and sub-group meta-analysis study","authors":"Vishal Dubey,&nbsp;Dharmeshkumar Kheni,&nbsp;Varun Sureja","doi":"10.1016/j.explore.2024.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><p>Osteoarthritis (OA) is a joint disease characterized by pain, inflammation, and physical disability. <em>Boswellia serrata</em> (BS) is widely studied for its effectiveness in OA condition. Our systematic review and meta-analysis study was aimed to evaluate BS extract efficacy in OA. A sub-group analysis was performed to compare the efficacy of a standardized BS extract (Aflapin<sup>Ⓡ</sup>) with other BS extracts.</p></div><div><h3>Methods</h3><p>Randomized controlled trials, identified from three online databases, evaluating the effect of BS extracts in OA were included. Quality of studies was assessed using PEDro scale and risk of bias was assessed using Cochrane Risk of Bias tool. Pooled effect was reported as mean difference (MD) and 95% confidence interval. Study was conducted as per the Cochrane guidelines (PROSPERO registration ID: CRD42023411356).</p></div><div><h3>Results</h3><p>Nine RCTs with 712 participants were included. All studies (except one) were good quality studies. BS supplementation significantly reduced VAS (MD: -10.71; p&lt;0.00001), LFI (MD: -2.99; p&lt;0.00001), WOMAC-pain (MD: -10.69; p&lt;0.0001), WOMAC-stiffness (MD: -5.49; p&lt;0.00001), and WOMAC-function (MD: -10.69; p&lt;0.00001) scores compared to control therapy. By sub-group analysis, Aflapin<sup>Ⓡ</sup> supplementation showed greater reduction in VAS (MD: -16.09 vs -4.68), LFI (MD: -3.81 vs -2.01), WOMAC-pain (MD: -18.68 vs -7.07), WOMAC-stiffness (MD: -14.25 vs -3.78), and WOMAC-function (MD: -14.99 vs -8.41) scores as compared to other BS therapies.</p></div><div><h3>Conclusions</h3><p>BS supplementation is effective OA symptomatic management. Sub-group analysis revealed that Aflapin<sup>Ⓡ</sup> supplementation may be better in improving the symptoms of OA which needs to be confirmed by more comparative clinical studies.</p></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 5","pages":"Article 102983"},"PeriodicalIF":1.9000,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Explore-The Journal of Science and Healing","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1550830724000090","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Background and purpose

Osteoarthritis (OA) is a joint disease characterized by pain, inflammation, and physical disability. Boswellia serrata (BS) is widely studied for its effectiveness in OA condition. Our systematic review and meta-analysis study was aimed to evaluate BS extract efficacy in OA. A sub-group analysis was performed to compare the efficacy of a standardized BS extract (Aflapin) with other BS extracts.

Methods

Randomized controlled trials, identified from three online databases, evaluating the effect of BS extracts in OA were included. Quality of studies was assessed using PEDro scale and risk of bias was assessed using Cochrane Risk of Bias tool. Pooled effect was reported as mean difference (MD) and 95% confidence interval. Study was conducted as per the Cochrane guidelines (PROSPERO registration ID: CRD42023411356).

Results

Nine RCTs with 712 participants were included. All studies (except one) were good quality studies. BS supplementation significantly reduced VAS (MD: -10.71; p<0.00001), LFI (MD: -2.99; p<0.00001), WOMAC-pain (MD: -10.69; p<0.0001), WOMAC-stiffness (MD: -5.49; p<0.00001), and WOMAC-function (MD: -10.69; p<0.00001) scores compared to control therapy. By sub-group analysis, Aflapin supplementation showed greater reduction in VAS (MD: -16.09 vs -4.68), LFI (MD: -3.81 vs -2.01), WOMAC-pain (MD: -18.68 vs -7.07), WOMAC-stiffness (MD: -14.25 vs -3.78), and WOMAC-function (MD: -14.99 vs -8.41) scores as compared to other BS therapies.

Conclusions

BS supplementation is effective OA symptomatic management. Sub-group analysis revealed that Aflapin supplementation may be better in improving the symptoms of OA which needs to be confirmed by more comparative clinical studies.

标准化乳香提取物(AflapinⓇ)对骨关节炎的疗效评估:系统综述和亚组荟萃分析研究。
背景和目的:骨关节炎(OA)是一种以疼痛、炎症和身体残疾为特征的关节疾病。乳香(BS)因其对骨关节炎的疗效而被广泛研究。我们的系统回顾和荟萃分析研究旨在评估乳香提取物对 OA 的疗效。我们还进行了分组分析,以比较标准化 BS 提取物(AflapinⓇ)与其他 BS 提取物的疗效:方法:纳入了从三个在线数据库中找到的评估 BS 提取物对 OA 效果的随机对照试验。研究质量采用 PEDro 量表进行评估,偏倚风险采用 Cochrane 偏倚风险工具进行评估。汇总效应以平均差(MD)和 95% 置信区间进行报告。研究按照 Cochrane 指南(PROSPERO 注册编号:CRD42023411356)进行:结果:共纳入 9 项研究,712 人参与。所有研究(一项除外)均为高质量研究。与其他 BS 疗法相比,补充 BS 可明显降低 VAS(MD:-10.71;pⓇ)、LFI(MD:-3.81 vs -2.01)、WOMAC-疼痛(MD:-18.68 vs -7.07)、WOMAC-僵硬(MD:-14.25 vs -3.78)和 WOMAC-功能(MD:-14.99 vs -8.41)评分:结论:补充 BS 可有效治疗 OA 症状。亚组分析显示,阿弗拉平Ⓡ补充剂在改善 OA 症状方面可能更好,这需要更多的临床对比研究来证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Explore-The Journal of Science and Healing
Explore-The Journal of Science and Healing 医学-全科医学与补充医学
CiteScore
3.00
自引率
8.30%
发文量
179
审稿时长
25 days
期刊介绍: EXPLORE: The Journal of Science & Healing addresses the scientific principles behind, and applications of, evidence-based healing practices from a wide variety of sources, including conventional, alternative, and cross-cultural medicine. It is an interdisciplinary journal that explores the healing arts, consciousness, spirituality, eco-environmental issues, and basic science as all these fields relate to health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信