Ubiquitin in autophagy and non-protein ubiquitination

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-02-16 DOI:10.1038/s41594-024-01217-6

Noboru Mizushima

引用次数: 0

Abstract

In addition to its role in proteasomal degradation, ubiquitin has multiple roles in autophagy. It can mark proteins for autophagic degradation and actively drive autophagosome formation. Recent work shows that ubiquitin can also be conjugated to phospholipids and other biomolecules.

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自噬和非蛋白质泛素化中的泛素

除了在蛋白酶体降解中发挥作用外，泛素还在自噬中发挥多重作用。它可以标记自噬降解的蛋白质，并积极推动自噬体的形成。最近的研究表明，泛素还可以与磷脂和其他生物大分子结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.