Evaluation of pan-Immuno-Inflammation value for In-hospital mortality in acute pulmonary embolism patients.

IF 1.4 4区医学 Q2 Medicine

Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2024-02-15 DOI:10.24875/RIC.23000290

Vedat Çiçek, Samet Yavuz, Faysal Şaylık, Şölen Taşlıçukur, Ahmet Öz, Mert Babaoğlu, Almina Erdem, İrem Yılmaz, Ulas Bagci, Tufan Cinar

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引用次数: 0

Abstract

Background: Pan-immuno-inflammation value (PIV) is a new and comprehensive index that reflects both the immune response and systemic inflammation in the body.

Objective: The aim of this study was to investigate the prognostic relevance of PIV in predicting in-hospital mortality in acute pulmonary embolism (PE) patients and to compare it with the well-known risk scoring system, PE severity index (PESI), which is commonly used for a short-term mortality prediction in such patients.

Methods: In total, 373 acute PE patients diagnosed with contrast-enhanced computed tomography were included in the study. Detailed cardiac evaluation of each patient was performed and PESI and PIV were calculated.

Results: In total, 60 patients died during their hospital stay. The multivariable logistic regression analysis revealed that baseline heart rate, N-terminal pro-B-type natriuretic peptide, lactate dehydrogenase, PIV, and PESI were independent risk factors for in-hospital mortality in acute PE patients. When comparing with PESI, PIV was non-inferior in terms of predicting the survival status in patients with acute PE.

Conclusion: In our study, we found that the PIV was statistically significant in predicting in-hospital mortality in acute PE patients and was non-inferior to the PESI.

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评估泛免疫炎症对急性肺栓塞患者院内死亡率的影响。

背景：泛免疫炎症值（PIV）是一项新的综合指标，可同时反映人体免疫反应和全身炎症：泛免疫炎症值（PIV）是一项新的综合指标，它能同时反映机体的免疫反应和全身炎症：本研究旨在探讨 PIV 在预测急性肺栓塞（PE）患者院内死亡率方面的预后相关性，并将其与常用于预测此类患者短期死亡率的著名风险评分系统 PE 严重程度指数（PESI）进行比较：研究共纳入了 373 名经对比增强计算机断层扫描确诊的急性 PE 患者。对每位患者进行了详细的心脏评估，并计算了 PESI 和 PIV：结果：共有 60 名患者在住院期间死亡。多变量逻辑回归分析显示，基线心率、N-末端前 B 型钠尿肽、乳酸脱氢酶、PIV 和 PESI 是急性 PE 患者院内死亡的独立危险因素。与 PESI 相比，PIV 在预测急性 PE 患者的生存状况方面并不逊色：在我们的研究中，我们发现 PIV 在预测急性 PE 患者的院内死亡率方面具有统计学意义，且不劣于 PESI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista De Investigacion Clinica-Clinical and Translational Investigation 医学-医学：内科

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews. Types of manuscripts: – Brief Communications – Research Letters – Original Articles – Brief Reviews – In-depth Reviews – Perspectives – Letters to the Editor