RNA therapeutics history and future perspectives.

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in Molecular Biology and Translational Science Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI:10.1016/bs.pmbts.2024.01.004

Hong-Quan Duong, Minh-Cong Hoang, Thi-Hue Nguyen, Van-Lang Ngo, Van-Thu Le

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引用次数: 0

Abstract

Ribonucleic acid (RNA) therapeutics have significantly used RNA-based drugs to the prevention and treatment of diseases as effective messenger RNA-based vaccines in response to the COVID-19 pandemic. The RNA therapeutics with five classes including antisense oligonucleotide, small interfering RNA, microRNA, APTAMER and messenger RNAs are being quickly developed to treat various human diseases as neurological disease, cardiovascular disease, genetic and rare disease, cancer disease, coronavirus disease… which cannot be treated by other conventional drugs as small molecule-based drugs and antibodies. Therefore, the discovery of these RNA therapeutics created a new avenue for treatment of various human diseases. This chapter demonstrates the history of important discoveries in RNA biology and their impact on key developments in RNA therapeutics as well as the advantages of RNA therapeutics; RNA therapeutics describes the action mechanisms and examples of RNA-based drugs approved for treatment of various disease; and RNA therapeutics discusses delivery methods for RNA therapeutics to target organs and cells. In conclusion, this chapter is designed to offer an updated important development and advance of RNA therapeutics for the prevention and treatment of various human diseases.

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RNA 疗法的历史与未来展望。

核糖核酸（RNA）疗法将 RNA 类药物广泛应用于疾病的预防和治疗，如应对 COVID-19 大流行的有效信使 RNA 疫苗。包括反义寡核苷酸、小干扰 RNA、microRNA、APTAMER 和信使 RNA 在内的五类 RNA 疗法正在迅速发展，以治疗神经系统疾病、心血管疾病、遗传病和罕见病、癌症、冠状病毒病等各种人类疾病。因此，这些 RNA 疗法的发现为治疗各种人类疾病开辟了一条新途径。本章展示了 RNA 生物学重要发现的历史及其对 RNA 治疗学关键发展的影响，以及 RNA 治疗学的优势；RNA 治疗学介绍了 RNA 药物的作用机制和已获批准用于治疗各种疾病的实例；RNA 治疗学讨论了将 RNA 治疗学药物输送到靶器官和细胞的方法。总之，本章旨在介绍 RNA 疗法在预防和治疗各种人类疾病方面的最新重要发展和进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Molecular Biology and Translational Science BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

5.00

自引率

0.00%

发文量

110

审稿时长

4-8 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.