Computational tools supporting known miRNA identification.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Van-Quy Do, Chuc Hoang-Thi, Thanh-Truong Pham, Nhat-Le Bui, Dinh-Thai Kim, Dinh-Toi Chu
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引用次数: 0

Abstract

The study of small RNAs is a field that is expanding quickly. Other functional short RNA molecules other than microRNAs, and gene expression regulators, have been found in animals and plants. MicroRNAs play a significant role in host-microbe interactions, and parasite microRNAs may affect the host's innate immunity. Furthermore, short RNAs are intriguing non-invasive biomarker possibilities because they can be found in physiological fluids. These trends suggest that for many researchers, quick and simple techniques for expression profiling and subsequent downstream analysis of miRNA-seq data are crucial. We selected sRNAtoolbox to make integrated sRNA research easier. Each tool can be used separately or to explore and analyze sRNAbench results in further depth. A special focus was placed on the tools' usability. We review available miRNA research tools to have an overview of the evaluation of the tools. Mainly we evaluate the tool sRNAtoolbox.

支持已知 miRNA 识别的计算工具。
对小 RNA 的研究是一个正在迅速扩展的领域。除 microRNA 外,在动物和植物中还发现了其他功能性短 RNA 分子和基因表达调控因子。microRNA 在宿主与微生物的相互作用中发挥着重要作用,寄生虫的 microRNA 可能会影响宿主的先天免疫力。此外,由于短 RNA 可在生理液体中发现,因此它们是令人感兴趣的非侵入性生物标记物。这些趋势表明,对许多研究人员来说,快速、简单的表达谱分析技术以及随后的 miRNA-seq 数据下游分析至关重要。我们选择了 sRNAtoolbox 来简化综合 sRNA 研究。每个工具都可以单独使用,也可以进一步深入探索和分析 sRNAbench 的结果。我们特别注重工具的可用性。我们回顾了现有的 miRNA 研究工具,以便对这些工具的评估有一个总体了解。我们主要评估了 sRNAtoolbox 工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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