Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.

IF 5.5 1区农林科学 Q1 IMMUNOLOGY

Virulence Pub Date : 2024-12-01 Epub Date: 2024-02-16 DOI:10.1080/21505594.2024.2316438

Natalie M Kirk, Yuying Liang, Hinh Ly

引用次数: 0

Abstract

Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.

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冠状病毒疾病的发病机制和毒力：COVID-19动物模型的病理学比较。

能够复制严重人类冠状病毒感染的临床和病理特征的动物模型在新型疫苗和疗法的开发中发挥了重要作用。本综述旨在总结我们目前对 2019 年冠状病毒病（COVID-19）发病机制的理解，以及在目前可用的几种动物模型中可以观察到的病理特征。从研究这些 SARS-CoV-2 感染动物模型中获得的知识有助于为疾病建模以及疫苗和疗法开发选择适当的模型提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virulence IMMUNOLOGY-MICROBIOLOGY

CiteScore

9.20

自引率

1.90%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.

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