Metabolic dysregulation of lymphocytes in autoimmune diseases.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-02-13 DOI:10.1016/j.tem.2024.01.005
Shuyi Wang, Niansheng Yang, Hui Zhang
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引用次数: 0

Abstract

Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.

自身免疫性疾病中淋巴细胞的代谢失调。
淋巴细胞对于抵御感染和癌症的保护性免疫至关重要;然而,免疫失调可导致自身免疫性疾病,如系统性红斑狼疮(SLE)和类风湿性关节炎(RA)。代谢适应性控制着淋巴细胞的命运;因此,代谢重编程可能有助于自身免疫性疾病的发病机制。在此,我们总结了有关代谢重编程如何决定系统性红斑狼疮和类风湿性关节炎中淋巴细胞的自反应性和促炎性的最新研究进展,揭示其分子机制,并为人类自身免疫性疾病提供治疗靶点。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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