The Impact of Oxidative Stress on Pregnancy. The Neglected Role of Alcohol Misuse.

Q2 Medicine
A D'Angelo, M Peracchini, A Agostini, C Di Matteo, M Fiore, M Ceccanti, M Vitali, M P Messina
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引用次数: 0

Abstract

Abstract: Oxygen is essential for human life. However, it could cause damaging effects on biological systems causing oxidative stress. Oxidative stress defined as "an alteration in the pro-oxidant-antioxidant balance in favor of the former that leads to potential damage" is characterized by the release of Reactive Oxygen Species (ROS). Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including complications of pregnancy such as placental pathology, PreEclampsia (PE), Intrauterine Growth Restriction (IUGR), gestational diabetes, and miscarriage. This narrative review aims to summarize pieces of evidence about the role of oxidative stress in the pathophysiology of the main obstetric complications with par-ticular interest in the neglected role of alcohol abuse.

氧化应激对妊娠的影响。被忽视的酗酒问题。
摘要:氧气是人类生命的必需品。然而,氧气会对生物系统造成破坏性影响,导致氧化应激。氧化应激被定义为 "有利于前者而导致潜在损害的促氧化-抗氧化平衡的改变",其特点是释放活性氧(ROS)。氧化应激目前被认为在许多不同疾病的病理生理学中起着核心作用,包括妊娠并发症,如胎盘病理学、子痫前期(PE)、宫内生长受限(IUGR)、妊娠糖尿病和流产。这篇叙述性综述旨在总结氧化应激在主要产科并发症的病理生理学中作用的证据,尤其关注被忽视的酗酒问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinica Terapeutica
Clinica Terapeutica PHARMACOLOGY & PHARMACY-
CiteScore
2.50
自引率
0.00%
发文量
124
审稿时长
6-12 weeks
期刊介绍: La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.
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