The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.

IF 4 2区医学 Q1 PSYCHIATRY

Borderline Personality Disorder and Emotion Dysregulation Pub Date : 2024-02-15 DOI:10.1186/s40479-024-00246-3

Oladapo Babajide, Alisa D Kjaergaard, Weichen Deng, Aleksander Kuś, Rosalie B T M Sterenborg, Bjørn Olav Åsvold, Stephen Burgess, Alexander Teumer, Marco Medici, Christina Ellervik, Bass Nick, Panos Deloukas, Eirini Marouli

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引用次数: 0

Abstract

Background: Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ.

Methods: We employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association.

Results: Genetically predicted higher FT4 was not associated with the risk of BPD (OR: 1.18; P = 0.60, IVW) or the risk of SCZ (OR: 0.93; P = 0.19, IVW). Genetically predicted higher TSH was not associated with the risk of BPD (OR: 1.11; P = 0.51, IVW) or SCZ (OR: 0.98, P = 0.55, IVW). Genetically predicted hypothyroidism was not associated with BPD or SCZ. We found no evidence for a reverse causal effect between BPD or SCZ on thyroid function.

Conclusions: We report evidence for a null association between genetically predicted FT4, TSH or hypothyroidism with BPD or SCZ risk. There was no evidence for reverse causality.

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甲状腺功能在边缘型人格障碍和精神分裂症中的作用：孟德尔随机研究。

背景：全基因组关联研究报告称，边缘型人格障碍（BPD）和精神分裂症（SCZ）之间存在遗传重叠。在流行病学上，甲状腺功能与 BPD 和 SCZ 风险之间的关联方向和因果关系尚不清楚。我们旨在检验TSH和FT4水平的遗传预测变异或甲状腺功能减退是否与BPD和SCZ的风险有关：我们使用与TSH和FT4水平以及甲状腺功能减退症相关的遗传工具进行了孟德尔随机（MR）分析，以检验遗传预测的甲状腺功能对BPD和SCZ风险的影响。双向MR分析用于研究潜在的反向因果关系：遗传预测的较高 FT4 与 BPD 风险（OR：1.18；P = 0.60，IVW）或 SCZ 风险（OR：0.93；P = 0.19，IVW）无关。遗传预测的较高 TSH 与 BPD（OR：1.11；P = 0.51，IVW）或 SCZ（OR：0.98；P = 0.55，IVW）的风险无关。基因预测的甲状腺功能减退与 BPD 或 SCZ 无关。我们没有发现证据表明BPD或SCZ对甲状腺功能有反向因果效应：我们报告的证据表明，遗传预测的FT4、TSH或甲状腺功能减退与BPD或SCZ风险之间没有关联。没有证据表明存在反向因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Borderline Personality Disorder and Emotion Dysregulation Psychology-Clinical Psychology

CiteScore

6.00

自引率

9.80%

发文量

审稿时长

28 weeks

期刊介绍： Borderline Personality Disorder and Emotion Dysregulation provides a platform for researchers and clinicians interested in borderline personality disorder (BPD) as a currently highly challenging psychiatric disorder. Emotion dysregulation is at the core of BPD but also stands on its own as a major pathological component of the underlying neurobiology of various other psychiatric disorders. The journal focuses on the psychological, social and neurobiological aspects of emotion dysregulation as well as epidemiology, phenomenology, pathophysiology, treatment, neurobiology, genetics, and animal models of BPD.