Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI:10.1080/13880209.2024.2314705
Shiyi Shen, Huiyun Zhong, Xiaoshi Zhou, Guolin Li, Changji Zhang, Yulian Zhu, Yong Yang
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引用次数: 0

Abstract

Context: Diabetic kidney disease (DKD) is a prominent complication arising from diabetic microangiopathy, and its prevalence and renal impact have placed it as the primary cause of end-stage renal disease. Traditional Chinese Medicine (TCM) has the distinct advantage of multifaceted and multilevel therapeutic attributes that show efficacy in improving clinical symptoms, reducing proteinuria, protecting renal function, and slowing DKD progression. Over recent decades, extensive research has explored the mechanisms of TCM for preventing and managing DKD, with substantial studies that endorse the therapeutic benefits of TCM compounds and single agents in the medical intervention of DKD.

Objective: This review lays the foundation for future evidence-based research efforts and provide a reference point for DKD investigation.

Methods: The relevant literature published in Chinese and English up to 30 June 2023, was sourced from PubMed, Cochrane Library, VIP Database for Chinese Technical Periodicals (VIP), Wanfang Data, CNKI, and China Biology Medicine disc (CBM). The process involved examining and summarizing research on TCM laboratory tests and clinical randomized controlled trials for DKD treatment.

Results and conclusions: The TCM intervention has shown the potential to inhibit the expression of inflammatory cytokines and various growth factors, lower blood glucose levels, and significantly affect insulin resistance, lipid metabolism, and improved renal function. Furthermore, the efficacy of TCM can be optimized by tailoring personalized treatment regimens based on the unique profiles of individual patients. We anticipate further rigorous and comprehensive clinical and foundational investigations into the mechanisms underlying the role of TCM in treating DKD.

中医药治疗糖尿病肾病的研究进展。
背景:糖尿病肾病(DKD)是糖尿病微血管病变引起的突出并发症,其发病率和对肾脏的影响使其成为终末期肾病的主要病因。中医药在改善临床症状、减少蛋白尿、保护肾功能、延缓 DKD 进展等方面具有多方面、多层次的显著疗效。近几十年来,大量研究探索了中医药预防和控制 DKD 的机制,其中大量研究认可了中药复方和单方在 DKD 医疗干预中的疗效:本综述为今后的循证研究工作奠定了基础,并为 DKD 研究提供了一个参考点:方法:从PubMed、Cochrane图书馆、中国科技期刊数据库(VIP)、万方数据、中国知网(CNKI)和中国生物医学文献数据库(CBM)中检索截至2023年6月30日发表的相关中英文文献。研究过程包括对中医实验室检查和临床随机对照试验治疗 DKD 的研究进行检查和总结:中医药干预具有抑制炎症细胞因子和各种生长因子的表达、降低血糖水平、显著影响胰岛素抵抗、脂代谢和改善肾功能的潜力。此外,还可以根据个体患者的独特情况,量身定制个性化的治疗方案,从而优化中医药的疗效。我们期待着对中药治疗 DKD 的作用机制开展进一步严格而全面的临床和基础研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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