Body Mass Index and All-Cause Mortality in Elderly Patients with Percutaneous Coronary Intervention: A Meta-Analysis.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI:10.1159/000537744

Yunhui Wang, Junwu Li, Yulian Zhang, Shiyu Chen, Fang Zheng, Wei Deng

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引用次数: 0

Abstract

Introduction: The "obesity paradox" in elderly patients suffering from percutaneous coronary intervention (PCI) remains a source of controversy. The present meta-analysis focused on exploring the real existence of "obesity paradox" in these patients.

Methods: As of November 2022, PubMed, Cochrane, and Embase databases were comprehensively searched to identify articles reporting all-cause mortality according to diverse body mass index (BMI) categories after PCI among the old cases developing coronary artery disease (CAD). Summary estimates of relative risks (RRs) were assigned to four BMI groups, including underweight, normal weight, overweight, and obesity groups.

Results: There were altogether nine articles involving 25,798 cases selected for further analysis. Relative to normal weight group, overweight and obesity groups had decreased all-cause mortality (RR: 0.86, 95% CI: 0.77-0.95 for overweight group; RR: 0.57, 95% CI: 0.40-0.80 for obesity group), while underweight group had elevated all-cause mortality (RR: 1.52, 95% CI: 1.01-2.29).

Conclusion: Our study revealed an "obesity paradox" relation of BMI with all-cause mortality in elderly cases receiving PCI. In comparison with normal weight group, overweight and obesity groups had decreased all-cause mortality, while underweight group had increased all-cause mortality.

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经皮冠状动脉介入治疗老年患者的体重指数与全因死亡率：荟萃分析

背景：经皮冠状动脉介入治疗（PCI）老年患者的 "肥胖悖论 "仍存在争议。本荟萃分析主要探讨这些患者是否真的存在 "肥胖悖论"：方法：截至 2022 年 11 月，我们对 PubMed、Cochrane 和 Embase 数据库进行了全面检索，以确定在发生冠状动脉疾病（CAD）的老年病例中，根据不同体重指数（BMI）类别报告 PCI 后全因死亡率的文章。对四个体重指数组（包括体重不足组、正常体重组、超重组和肥胖组）的风险比（RRs）进行了汇总估算：共有九篇文章，涉及 25,798 个病例被选作进一步分析。与正常体重组相比，超重组和肥胖组的全因死亡率有所下降（超重组的 RR 为 0.86，95%CI 为 0.77-0.95；肥胖组的 RR 为 0.57，95%CI 为 0.40-0.80），而体重不足组的全因死亡率有所上升（RR 为 1.52，95%CI 为 1.01-2.29）：我们的研究揭示了在接受PCI治疗的老年病例中，体重指数与全因死亡率之间的 "肥胖悖论 "关系。与正常体重组相比，超重组和肥胖组的全因死亡率下降，而体重不足组的全因死亡率上升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.