Combining PLGA microspheres loaded with Liver X receptor agonist GW3965 with a chitosan nerve conduit can promote the healing and regeneration of the wounded sciatic nerve

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-02-14 DOI:10.1002/jbm.b.35378

Yuanwu Zhong, Shiqi Li, Yanzhen Chen, Yuan Tang, Xinmao Xiao, Tao Nie

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引用次数: 0

Abstract

Globally, peripheral nerve injury (PNI) is a common clinical issue. Successfully repairing severe PNIs has posed a major challenge for clinicians. GW3965 is a highly selective LXR agonist, and previous studies have demonstrated its positive protective effects in both central and peripheral nerve diseases. In this work, we examined the potential reparative effects of GW3965-loaded polylactic acid co-glycolic acid microspheres in conjunction with a chitosan nerve conduit for peripheral nerve damage. The experiment revealed that GW3965 promoted Schwann cell proliferation and neurotrophic factor release in vitro. In vivo experiments conducted on rats showed that GW3965 facilitated the restoration of motor function, promoted axon and myelin regeneration in the sciatic nerve, and enhanced the microenvironment of nerve regeneration. These results offer a novel therapeutic approach for the healing of nerve damage. Overall, this work provides valuable insights and presents a promising therapeutic strategy for addressing PNI.

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将负载肝X受体激动剂GW3965的PLGA微球与壳聚糖神经导管相结合，可促进损伤坐骨神经的愈合和再生。

在全球范围内，周围神经损伤（PNI）是一个常见的临床问题。如何成功修复严重的周围神经损伤是临床医生面临的一大挑战。GW3965 是一种高选择性 LXR 激动剂，之前的研究已经证明了它对中枢神经和周围神经疾病的积极保护作用。在这项工作中，我们研究了 GW3965 负载的聚乳酸共聚乙醇酸微球与壳聚糖神经导管结合对周围神经损伤的潜在修复作用。实验显示，GW3965 在体外促进了许旺细胞的增殖和神经营养因子的释放。在大鼠身上进行的体内实验表明，GW3965 能促进运动功能的恢复，促进坐骨神经轴突和髓鞘的再生，并改善神经再生的微环境。这些结果为神经损伤的愈合提供了一种新的治疗方法。总之，这项工作提供了有价值的见解，并提出了一种很有希望的治疗策略来解决 PNI 问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.