Mechanism of Acupuncture in Treating Obesity: Advances and Prospects.

The American journal of Chinese medicine Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI:10.1142/S0192415X24500010
Mi-Na Wang, Miao-Xin Zhai, Yi-Tong Wang, Qiu-Fu Dai, Lu Liu, Luo-Peng Zhao, Qiu-Yu Xia, Shen Li, Bin Li
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Abstract

Obesity is a common metabolic syndrome that causes a significant burden on individuals and society. Conventional therapies include lifestyle interventions, bariatric surgery, and pharmacological therapies, which are not effective and have a high risk of adverse events. Acupuncture is an effective alternative for obesity, it modulates the hypothalamus, sympathetic activity and parasympathetic activity, obesity-related hormones (leptin, ghrelin, insulin, and CCK), the brain-gut axis, inflammatory status, adipose tissue browning, muscle blood flow, hypoxia, and reactive oxygen species (ROS) to influence metabolism, eating behavior, motivation, cognition, and the reward system. However, hypothalamic regulation by acupuncture should be further demonstrated in human studies using novel techniques, such as functional MRI (fMRI), positron emission tomography (PET), electroencephalogram (EEG), and magnetoencephalography (MEG). Moreover, a longer follow-up phase of clinical trials is required to detect the long-term effects of acupuncture. Also, future studies should investigate the optimal acupuncture therapeutic option for obesity. This review aims to consolidate the recent improvements in the mechanism of acupuncture for obesity as well as discuss the future research prospects and potential of acupuncture for obesity.

针灸治疗肥胖症的机制:进展与前景》。
肥胖症是一种常见的代谢综合征,给个人和社会带来沉重负担。传统疗法包括生活方式干预、减肥手术和药物疗法,但效果不佳且不良反应风险较高。针灸是治疗肥胖症的有效替代疗法,它能调节下丘脑、交感神经活动和副交感神经活动、肥胖相关激素(瘦素、胃泌素、胰岛素和 CCK)、脑-肠轴、炎症状态、脂肪组织褐变、肌肉血流、缺氧和活性氧(ROS),从而影响新陈代谢、饮食行为、动机、认知和奖赏系统。然而,针灸对下丘脑的调节作用还需要在人体研究中使用功能磁共振成像(fMRI)、正电子发射断层扫描(PET)、脑电图(EEG)和脑磁图(MEG)等新技术进一步证实。此外,还需要对临床试验进行更长时间的随访,以检测针灸的长期效果。此外,未来的研究还应探讨针灸治疗肥胖症的最佳方案。本综述旨在总结针灸治疗肥胖症机制的最新进展,并探讨针灸治疗肥胖症的未来研究前景和潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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