Directing RNA-modifying machineries towards endogenous RNAs: opportunities and challenges.

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI:10.1016/j.tig.2024.01.001

Monika Witzenberger, Schraga Schwartz

引用次数: 0

Abstract

Over 170 chemical modifications can be naturally installed on RNA, all of which are catalyzed by dedicated machineries. These modifications can alter RNA sequence structure, stability, and translation as well as serving as quality control marks that record aspects of RNA processing. The diverse roles played by RNAs within cells has motivated endeavors to exogenously introduce RNA modifications at target sites for diverse purposes ranging from recording RNA:protein interactions to therapeutic applications. Here, we discuss these applications and the approaches that have been employed to engineer RNA-modifying machineries, and highlight persisting challenges and perspectives.

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将 RNA 修改机制引向内源性 RNA：机遇与挑战。

RNA 上可以自然安装 170 多种化学修饰，所有这些修饰都由专用机器催化。这些修饰可改变 RNA 序列结构、稳定性和翻译，还可作为记录 RNA 处理过程的质量控制标志。RNA 在细胞内发挥的作用多种多样，这促使人们努力在目标位点外源引入 RNA 修饰，以实现从记录 RNA 与蛋白质相互作用到治疗应用等多种目的。在此，我们将讨论这些应用以及用于设计 RNA 修饰机制的方法，并强调持续存在的挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.