[Features of lung damage in baclofen poisoning].

Q4 Medicine

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI:10.17116/sudmed20246701129

O L Romanova, M L Blagonravov, P G Djuvalyakov, E Kh Barinov, A V Ershov, M A Kislov

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引用次数: 0

Abstract

Objective: To reveal pathological lung changes in baclofen poisoning and to assess their dynamics.

Material and methods: The experiment included 20 mature (at age 20 weeks) male rats of Wistar line weighing 290-350 gr. The animals were divided into 3 study groups (5 rats in each) depending on experiment's duration after 85 mg/kg baclofen administration: 3, 4.5 and 24 h in the 1st, 2nd and 3rd groups, respectively. Control group consisted of 5 animals without baclofen administration.

Results: A number of pathological reactions, including circulatory disorder (venular and capillary congestion, hemorrhage in interalveolar septa, alveoli, sludge) and the appearance of emphysema loci (interalveolar septa at emphysema loci are thinned), alternating with atelectases and dystelectases. The area taken up by vessels after 4.5 h. baclofen administration was statistically significantly higher than in control group, and after 24 h. - statistically significantly higher than in 4.5 h. The area with white blood cells and WBC/IAP ratio after 4.5 h of baclofen administration were statistically significantly higher than in control group after 3 and 24 h of administration. The number of white blood cells, giving PAS positive reaction, increases during baclofen administration. The complex of pathological lung changes, revealed by ourselves, has a certain dynamics.

Conclusion: The data on morphological lung changes combined with results of chemical examination can be used to diagnose baclofen poisoning and to determine the time elapsed since this medicine administration.

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[巴氯芬中毒肺损伤的特征]。

目的：揭示巴氯芬中毒的肺部病理变化并评估其动态变化：揭示巴氯芬中毒的肺部病理变化并评估其动态变化：实验包括 20 只成熟（20 周龄）的 Wistar 系雄性大鼠，体重为 290-350 克。根据 85 毫克/千克巴氯芬给药后的实验持续时间，将动物分为 3 个研究组（每组 5 只）：第一、第二和第三组分别为 3、4.5 和 24 小时。对照组由 5 只未服用巴氯芬的大鼠组成：出现了一系列病理反应，包括循环障碍（静脉和毛细血管充血、肺泡间隔出血、肺泡出血、淤血）和肺气肿病灶（肺气肿病灶处的肺泡间隔变薄），并交替出现脑电解质酶和脑电解质酶。据统计，服用巴氯芬 4.5 小时后，血管所占面积明显高于对照组；服用 24 小时后，血管所占面积明显高于服用 4.5 小时后。在服用巴氯芬期间，出现 PAS 阳性反应的白细胞数量增加。我们所发现的肺部病理变化的复合体具有一定的动态性：肺部形态学变化数据与化学检查结果相结合，可用于诊断巴氯芬中毒，并确定用药后的时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sudebno-Meditsinskaya Ekspertisa Medicine-Pathology and Forensic Medicine

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.