Potent bioactive metabolites from Olea ferruginea

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-19 DOI:10.1080/14786419.2024.2315592

Nisar Ahmad , Yan Wang , M. Iqbal Choudhary , Sheema , Rasool Khan , Salman Zafar

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引用次数: 0

Abstract

Seven known (1-7) and one new compound (8) were isolated and identified from the stem of Olea ferruginea. The species has been recognised as a new source for six of the known metabolites (1, 3, 4, 5, 6, and 7). Based on detailed spectroscopic analyses, these compounds were identified as scopoletin (1), 8-ketosetosterol (2), (+)-cycloolivil (3), (+)-africanal (4), isovanilic acid (5), hydroxytyrosol acetate (6), vanillic acid (7), and cycloolivil A (8). The crude extracts and purified compounds were analysed for their Leishmanicidal, anti-glycation, anti-cancer, and anti-inflammatory activities. n-Hexane fraction was found to be the most active (among all the fractions), against Leishmania parasites, exhibiting 97.85% inhibition at 15 μg/mL. However, none of the extracts showed any significant anti-glycation or anti-cancer potential, all the fractions, except the aqueous layer, displayed moderate to low anti-inflammatory activity. Compound 1 was found to have strong anti-inflammatory activity, exhibiting 96.7% stimulation at 25 μg/mL.

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从 Olea ferruginea 中提取的强效生物活性代谢物。

从 Olea ferruginea 的茎中分离并鉴定出了七种已知化合物（1-7）和一种新化合物（8）。该物种被认为是六种已知代谢物（1、3、4、5、6 和 7）的新来源。根据详细的光谱分析，这些化合物被鉴定为莨菪亭（1）、8-酮酮甾醇（2）、(+)-cycloolivil（3）、(+)-africanal（4）、异香兰酸（5）、羟基酪醇醋酸酯（6）、香草酸（7）和 cycloolivil A（8）。对粗提取物和纯化化合物进行了杀利什曼、抗糖化、抗癌和抗炎活性分析。发现正己烷馏分（在所有馏分中）对利什曼寄生虫的活性最高，在 15 μg/mL 的浓度下显示出 97.85% 的抑制率。然而，没有一种提取物显示出明显的抗糖化或抗癌潜力，除水层外，所有馏分都显示出中等至较低的抗炎活性。研究发现，化合物 1 具有很强的抗炎活性，在 25 μg/mL 的浓度下显示出 96.7% 的刺激作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.