The 50th anniversary of the European Society for Muscle Research: a journey through half a century of scientific advances.

IF 1.8 3区 生物学 Q4 CELL BIOLOGY
Ger Stienen, Carlo Reggiani
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引用次数: 0

Abstract

The European Society for Muscle Research (ESMR) started in 1971 as "European Muscle Club" in a joint initiative of Marcus Schaub, Eduard Jenny and Rudolf Billeter (Zurich), Caspar Rüegg (Heidelberg), Jean Légér (Montpellier), Bernard Swynghedauw (Paris), George Maréchal (Brussels), Gabriel Hamoir (Liège), and Endre Biró (Budapest). Since 1972, local organizers took care of muscle conferences held yearly in different European countries and in Israel in 1987. One of the goals was to establish contacts and collaborations between scientists on both sides of the Iron Curtain. Starting as an informal club, enthusiastically guided by Marcus Schaub as secretary (1971-1995) and later by Ger Stienen (1996-2005), Anders Arner (2006-2017) and Wolfgang Linke (2018-), the ESMR meetings steered international collaborations. The meetings witnessed the remarkable advancement of the insight in skeletal, smooth and cardiac muscle structure and function. In the five decades, the thin and thick filament structure has been resolved to the atomic level, the mechanism of acto-myosin energy transduction and force generation as well as its regulation have been elucidated. The molecular basis of striated and smooth muscle diversity has been found in the existence of multiple protein isoforms. The transcriptional, translational and post-translational regulations which give rise to adaptive responses of muscle tissue have been revealed. Many new players entered the field, such as titin, the ryanodine receptor and several signalling factors. Substantial progress has also been made in the identification of the pathogenesis of many hereditary muscle diseases such as Duchenne MuscularDystrophy and Hypertrophic Cardiac Myopathies.

欧洲肌肉研究学会成立 50 周年:半个世纪的科学进步之旅。
欧洲肌肉研究学会(ESMR)成立于 1971 年,当时名为 "欧洲肌肉俱乐部",由 Marcus Schaub、Eduard Jenny 和 Rudolf Billeter(苏黎世)、Caspar Rüegg(海德堡)、Jean Légér(蒙彼利埃)、Bernard Swynghedauw(巴黎)、George Maréchal(布鲁塞尔)、Gabriel Hamoir(列日)和 Endre Biró(布达佩斯)联合发起。自 1972 年以来,当地的组织者负责每年在不同的欧洲国家和 1987 年在以色列举行的肌肉会议。目标之一是在铁幕两侧的科学家之间建立联系与合作。作为一个非正式的俱乐部,ESMR 会议最初由马库斯-肖布(Marcus Schaub)担任秘书(1971-1995 年),后来由格-斯蒂宁(Ger Stienen,1996-2005 年)、安德斯-阿尔纳(Anders Arner,2006-2017 年)和沃尔夫冈-林克(Wolfgang Linke,2018 年)热情指导,引导国际合作。这些会议见证了人们对骨骼肌、平滑肌和心肌结构与功能的深入了解取得了显著进展。五十年来,细丝和粗丝结构已被解析到原子水平,肌动蛋白能量转移和肌力产生的机制及其调控已被阐明。横纹肌和平滑肌多样性的分子基础在于多种蛋白质同工酶的存在。揭示了引起肌肉组织适应性反应的转录、翻译和翻译后调控。许多新的参与者进入了这一领域,如 titin、ryanodine 受体和一些信号因子。在确定许多遗传性肌肉疾病(如杜氏肌营养不良症和肥厚性心肌病)的发病机制方面也取得了重大进展。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
21
审稿时长
>12 weeks
期刊介绍: The Journal of Muscle Research and Cell Motility has as its main aim the publication of original research which bears on either the excitation and contraction of muscle, the analysis of any one of the processes involved therein, the processes underlying contractility and motility of animal and plant cells, the toxicology and pharmacology related to contractility, or the formation, dynamics and turnover of contractile structures in muscle and non-muscle cells. Studies describing the impact of pathogenic mutations in genes encoding components of contractile structures in humans or animals are welcome, provided they offer mechanistic insight into the disease process or the underlying gene function. The policy of the Journal is to encourage any form of novel practical study whatever its specialist interest, as long as it falls within this broad field. Theoretical essays are welcome provided that they are concise and suggest practical ways in which they may be tested. Manuscripts reporting new mutations in known disease genes without validation and mechanistic insight will not be considered. It is the policy of the journal that cells lines, hybridomas and DNA clones should be made available by the developers to any qualified investigator. Submission of a manuscript for publication constitutes an agreement of the authors to abide by this principle.
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