Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics.

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Beilstein Journal of Nanotechnology Pub Date : 2024-02-06 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.17
Phuong-Thao Dang-Luong, Hong-Phuc Nguyen, Loc Le-Tuan, Xuan-Thang Cao, Vy Tran-Anh, Hieu Vu Quang
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Abstract

Theragnostics has become a popular term nowadays, since it enables both diagnosis and therapy at the same time while only using one carrier platform. Therefore, formulating a nanocarrier system that could serve as theragnostic agent by using simple techniques would be an advantage during production. In this project, we aimed to develop a nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl alcohol)-based nanoparticles (NPs) using the single emulsion technique. Then the NPs were coated with F127 and F127-folate by simple incubation for five days. The nanoparticles have the hydrodynamic size of approx. 250 nm with negative charge. Similar to chlorambucil and IR780, iron oxide loadings were observed for all three kinds of NPs. The release of chlorambucil was quicker at pH 5.4 than at pH 7.4 at 37 °C. The F127@NPs and F127-folate@NPs demonstrated much greater cell uptake and toxicity up to 72 h after incubation. Our in vitro results of F127@NPs and F127-folate@NPs have demonstrated the ability of these systems to serve as medication and imaging agent carriers for cancer treatment and diagnostics, respectively.

装载有 IR780、氧化铁纳米颗粒和氯霉素的纳米载体系统,用于癌症治疗。
如今,"热诊断 "已成为一个流行词,因为它只需使用一个载体平台,就能同时进行诊断和治疗。因此,利用简单的技术配制出一种可用作热诊断剂的纳米载体系统将是生产过程中的一大优势。在本项目中,我们旨在开发一种可装载化疗药物氯霉素和磁共振成像剂(如氧化铁纳米粒子和近红外荧光团 IR780)的纳米载体,用于治疗。采用单一乳液技术,将聚乳酸-共聚乙醇酸与上述成分结合生成聚乙烯醇基纳米粒子(NPs)。然后,通过简单的培养,将 F127 和 F127-叶酸包覆在 NPs 上五天。这种纳米粒子的流体力学尺寸约为 250 nm,带负电荷。与氯霉素和 IR780 相似,所有三种 NPs 都含有氧化铁。在 37 °C、pH 值为 5.4 的条件下,氯霉素的释放速度比 pH 值为 7.4 的条件下快。F127@NPs 和 F127-叶酸@NPs 在培养 72 小时后的细胞摄取量和毒性都要大得多。我们对 F127@NPs 和 F127-叶酸@NPs 的体外研究结果表明,这些系统能够分别作为药物和成像剂载体用于癌症治疗和诊断。
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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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